Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed∼ 480 …
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed∼ 480 …
Telomere length, telomere‐related genes, and breast cancer risk: the breast cancer health disparities study
AJ Pellatt, RK Wolff, G Torres‐Mejia… - Genes …, 2013 - Wiley Online Library
Telomeres are involved in maintaining genomic stability. Previous studies have linked both
telomere length (TL) and telomere‐related genes with cancer. We evaluated associations …
telomere length (TL) and telomere‐related genes with cancer. We evaluated associations …
Genetic variation in five genes important in telomere biology and risk for breast cancer
SA Savage, SJ Chanock, J Lissowska… - British journal of …, 2007 - nature.com
Telomeres, consisting of TTAGGG nucleotide repeats and a protein complex at chromosome
ends, are critical for maintaining chromosomal stability. Genomic instability, following …
ends, are critical for maintaining chromosomal stability. Genomic instability, following …
Variation at the TERT locus and predisposition for cancer
DM Baird - Expert reviews in molecular medicine, 2010 - cambridge.org
Telomerase and the control of telomere length are intimately linked to the process of
tumourigenesis in humans. Here I review the evidence that variation at the 5p15. 33 locus …
tumourigenesis in humans. Here I review the evidence that variation at the 5p15. 33 locus …
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …
hTERT Cancer Risk Genotypes Are Associated With Telomere Length
BS Melin, K Nordfjäll, U Andersson… - Genetic …, 2012 - Wiley Online Library
Telomere biology is associated with cancer initiation and prognosis. Collected data suggest
that blood cell telomere length (TL) can change over time, which may be related to …
that blood cell telomere length (TL) can change over time, which may be related to …
Genetic variants in telomere-maintaining genes and skin cancer risk
H Nan, AA Qureshi, J Prescott, I De Vivo, J Han - Human genetics, 2011 - Springer
Telomere-related genes play an important role in maintaining the integrity of the telomeric
structure that protects chromosome ends, and telomere dysfunction may lead to …
structure that protects chromosome ends, and telomere dysfunction may lead to …
The association of telomere length and genetic variation in telomere biology genes a
Telomeres cap chromosome ends and are critical for genomic stability. Many telomere‐
associated proteins are important for telomere length maintenance. Recent genome‐wide …
associated proteins are important for telomere length maintenance. Recent genome‐wide …
Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis
S Mocellin, D Verdi, KA Pooley, MT Landi… - Journal of the …, 2012 - academic.oup.com
Background Several recent studies have provided evidence that polymorphisms in the
telomerase reverse transcriptase (TERT) gene sequence are associated with cancer …
telomerase reverse transcriptase (TERT) gene sequence are associated with cancer …
Cancer-associated TERT promoter mutations abrogate telomerase silencing
Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most
frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis …
frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis …
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