Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

SE Bojesen, KA Pooley, SE Johnatty, J Beesley… - Nature …, 2013 - nature.com
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed∼ 480 …

Telomere length, telomere‐related genes, and breast cancer risk: the breast cancer health disparities study

AJ Pellatt, RK Wolff, G Torres‐Mejia… - Genes …, 2013 - Wiley Online Library
Telomeres are involved in maintaining genomic stability. Previous studies have linked both
telomere length (TL) and telomere‐related genes with cancer. We evaluated associations …

Genetic variation in five genes important in telomere biology and risk for breast cancer

SA Savage, SJ Chanock, J Lissowska… - British journal of …, 2007 - nature.com
Telomeres, consisting of TTAGGG nucleotide repeats and a protein complex at chromosome
ends, are critical for maintaining chromosomal stability. Genomic instability, following …

Variation at the TERT locus and predisposition for cancer

DM Baird - Expert reviews in molecular medicine, 2010 - cambridge.org
Telomerase and the control of telomere length are intimately linked to the process of
tumourigenesis in humans. Here I review the evidence that variation at the 5p15. 33 locus …

Systematic analysis of telomere length and somatic alterations in 31 cancer types

FP Barthel, W Wei, M Tang, E Martinez-Ledesma… - Nature …, 2017 - nature.com
Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …

hTERT Cancer Risk Genotypes Are Associated With Telomere Length

BS Melin, K Nordfjäll, U Andersson… - Genetic …, 2012 - Wiley Online Library
Telomere biology is associated with cancer initiation and prognosis. Collected data suggest
that blood cell telomere length (TL) can change over time, which may be related to …

Genetic variants in telomere-maintaining genes and skin cancer risk

H Nan, AA Qureshi, J Prescott, I De Vivo, J Han - Human genetics, 2011 - Springer
Telomere-related genes play an important role in maintaining the integrity of the telomeric
structure that protects chromosome ends, and telomere dysfunction may lead to …

The association of telomere length and genetic variation in telomere biology genes a

L Mirabello, K Yu, P Kraft, I De Vivo, DJ Hunter… - Human …, 2010 - Wiley Online Library
Telomeres cap chromosome ends and are critical for genomic stability. Many telomere‐
associated proteins are important for telomere length maintenance. Recent genome‐wide …

Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis

S Mocellin, D Verdi, KA Pooley, MT Landi… - Journal of the …, 2012 - academic.oup.com
Background Several recent studies have provided evidence that polymorphisms in the
telomerase reverse transcriptase (TERT) gene sequence are associated with cancer …

Cancer-associated TERT promoter mutations abrogate telomerase silencing

K Chiba, JZ Johnson, JM Vogan, T Wagner, JM Boyle… - elife, 2015 - elifesciences.org
Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most
frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis …