Polycomb group (PcG) proteins form transcriptional repressor complexes with well‐
established functions during cell‐fate determination. Yet, the mechanisms underlying their …

In the developing mammalian nervous system, common progenitors integrate both cell
extrinsic and intrinsic regulatory programs to produce distinct neuronal and glial cell types …

The neocortex is considered the seat of higher cognitive function in humans. It develops
from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This …

Polycomb group (PcG) proteins are epigenetic modifiers involved in controlling gene
repression. Organized within multiprotein complexes, they regulate developmental genes in …

The study of mammalian corticogenesis has revealed a critical role for Polycomb group
(PcG) factors in timing the execution of developmental choices. Meanwhile, the study of post …

During neocortical development, neural precursor cells (NPCs, or neural stem cells)
produce neurons first and astrocytes later. Although the timing of the fate switch from …

The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential
for embryonic development and stem cell renewal and are commonly deregulated in cancer …

Polycomb group proteins (PcGs) are involved in gene repression through chromatin
modifications and required for the maintenance of both embryonic and adult stem cells …

Polycomb group (PcG) proteins are conserved epigenetic transcriptional repressors that
control numerous developmental gene expression programs and have recently been …

Precise control of gene expression patterns is critical for the specification of cellular diversity
during metazoan development. Polycomb group (PcG) proteins comprise a class of …