Macrophages are among the most abundant cells in the respiratory tract, and they can have
strikingly different phenotypes within this environment. Our knowledge of the different …

Macrophages are the most numerous immune-cells present in the lung environment under
homoeostatic conditions and are ideally positioned to dictate the innate defence of the …

In the healthy lung, macrophages maintain homeostasis by clearing inhaled particles,
bacteria, and removing apoptotic cells from the local pulmonary environment. However, in …

Macrophages are a major cellular component of the innate immune system, and play an
important role in the recognition of microbes, particulates, and immunogens and to the …

The lung is exposed to a vast array of inhaled antigens, particulate matter, and pollution.
Cells present in the airways must therefore be maintained in a generally suppressive …

Lung macrophages (LMs) are essential immune effector cells that are pivotal in both innate
and adaptive immune responses to inhaled foreign matter. They either reside within the …

The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

Macrophages act as immune scavengers and are important cell types in the homeostasis of
various tissues. Given the multiple roles of macrophages, these cells can also be found as …

Interest in pulmonary macrophage research has greatly increased as is now possible not
only to work with the easily accessible alveolar macrophages but also with macrophages …

The lungs present a challenging immunological dilemma for the host. Anatomically
positioned at the environmental interface, they are constantly exposed to antigens …