[HTML][HTML] Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle
RJW Middelbeek, MA Chambers, P Tantiwong… - Nutrition & …, 2013 - nature.com
METHODS: Here, lean, obese and T2D subjects underwent a euglycemic-hyperinsulinemic
clamp, and vastus lateralis muscle biopsies were obtained before, and at 30 and 180 min …
clamp, and vastus lateralis muscle biopsies were obtained before, and at 30 and 180 min …
Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise
MH Vendelbo, AB Møller, JT Treebak… - Journal of applied …, 2014 - journals.physiology.org
Background: phosphorylation of AS160 and TBC1D1 plays an important role for GLUT4
mobilization to the cell surface. The phosphorylation of AS160 and TBC1D1 in humans in …
mobilization to the cell surface. The phosphorylation of AS160 and TBC1D1 in humans in …
Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle
S Ducommun, HY Wang, K Sakamoto… - American Journal …, 2012 - journals.physiology.org
AS160 and its closely related protein TBC1D1 have emerged as key mediators for both
insulin-and contraction-stimulated muscle glucose uptake through regulating GLUT4 …
insulin-and contraction-stimulated muscle glucose uptake through regulating GLUT4 …
[HTML][HTML] Roles of TBC1D1 and TBC1D4 in insulin-and exercise-stimulated glucose transport of skeletal muscle
GD Cartee - Diabetologia, 2015 - Springer
This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1
Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 …
Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 …
Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle
A single exercise bout can increase insulin-independent glucose transport immediately
postexercise and insulin-dependent glucose transport (GT) for several hours postexercise …
postexercise and insulin-dependent glucose transport (GT) for several hours postexercise …
Exercise increases TBC1D1 phosphorylation in human skeletal muscle
Exercise and weight loss are cornerstones in the treatment and prevention of type 2
diabetes, and both interventions function to increase insulin sensitivity and glucose uptake …
diabetes, and both interventions function to increase insulin sensitivity and glucose uptake …
[HTML][HTML] Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle
JT Treebak, C Frøsig, C Pehmøller, S Chen… - Diabetologia, 2009 - Springer
Aims/hypothesis TBC1 domain family, member 4 (TBC1D4; also known as AS160) is a
cellular signalling intermediate to glucose transport regulated by insulin-dependent and …
cellular signalling intermediate to glucose transport regulated by insulin-dependent and …
Inhibition of contraction-stimulated AMP-activated protein kinase inhibits contraction-stimulated increases in PAS-TBC1D1 and glucose transport without altering PAS …
OBJECTIVE Phosphorylation of two members of the TBC1 domain family of proteins, Akt
substrate of 160 kDa (AS160, also known as TBC1D4) and TBC1D1, has been implicated in …
substrate of 160 kDa (AS160, also known as TBC1D4) and TBC1D1, has been implicated in …
TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction
R Kjøbsted, JM Kristensen, NO Eskesen, K Kido… - Diabetes, 2023 - Am Diabetes Assoc
The ability of insulin to stimulate glucose uptake in skeletal muscle is important for whole-
body glycemic control. Insulin-stimulated skeletal muscle glucose uptake is improved in the …
body glycemic control. Insulin-stimulated skeletal muscle glucose uptake is improved in the …
[HTML][HTML] Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored …
BF Vind, C Pehmøller, JT Treebak, JB Birk… - Diabetologia, 2011 - Springer
Aims/hypothesis Insulin-mediated glucose disposal rates (R d) are reduced in type 2
diabetic patients, a process in which intrinsic signalling defects are thought to be involved …
diabetic patients, a process in which intrinsic signalling defects are thought to be involved …