METHODS: Here, lean, obese and T2D subjects underwent a euglycemic-hyperinsulinemic
clamp, and vastus lateralis muscle biopsies were obtained before, and at 30 and 180 min …

Background: phosphorylation of AS160 and TBC1D1 plays an important role for GLUT4
mobilization to the cell surface. The phosphorylation of AS160 and TBC1D1 in humans in …

AS160 and its closely related protein TBC1D1 have emerged as key mediators for both
insulin-and contraction-stimulated muscle glucose uptake through regulating GLUT4 …

This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1
Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 …

A single exercise bout can increase insulin-independent glucose transport immediately
postexercise and insulin-dependent glucose transport (GT) for several hours postexercise …

Exercise and weight loss are cornerstones in the treatment and prevention of type 2
diabetes, and both interventions function to increase insulin sensitivity and glucose uptake …

Aims/hypothesis TBC1 domain family, member 4 (TBC1D4; also known as AS160) is a
cellular signalling intermediate to glucose transport regulated by insulin-dependent and …

OBJECTIVE Phosphorylation of two members of the TBC1 domain family of proteins, Akt
substrate of 160 kDa (AS160, also known as TBC1D4) and TBC1D1, has been implicated in …

The ability of insulin to stimulate glucose uptake in skeletal muscle is important for whole-
body glycemic control. Insulin-stimulated skeletal muscle glucose uptake is improved in the …

Aims/hypothesis Insulin-mediated glucose disposal rates (R d) are reduced in type 2
diabetic patients, a process in which intrinsic signalling defects are thought to be involved …