Interaction between TGF-β and ACE2-Ang-(1–7)-Mas pathway in high glucose-cultured NRK-52E cells
CH Chou, LY Chuang, CY Lu, JY Guh - Molecular and cellular …, 2013 - Elsevier
Transforming growth factor-β (TGF-β) is pivotal in diabetic nephropathy (DN). Angiotensin
converting enzyme-2 (ACE2) converts angiotensin II (Ang II) to angiotensin 1–7 (Ang–(1–7)) …
converting enzyme-2 (ACE2) converts angiotensin II (Ang II) to angiotensin 1–7 (Ang–(1–7)) …
Enhanced angiotensin-converting enzyme 2 attenuates angiotensin II-induced collagen production via AT1 receptor–phosphoinositide 3-kinase–Akt pathway
L Bu, S Qu, X Gao, JJ Zou, W Tang, LL Sun, ZM Liu - Endocrine, 2011 - Springer
Recent reports support a protective role for angiotensin-converting enzyme 2 (ACE2)
against glomerular diseases, especially by decreasing of extracellular matrix (ECM) …
against glomerular diseases, especially by decreasing of extracellular matrix (ECM) …
Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition
CX Liu, Q Hu, Y Wang, W Zhang, ZY Ma, JB Feng… - Molecular …, 2011 - Springer
The reduced expression of angiotensin-converting enzyme (ACE) 2 in the kidneys of animal
models and patients with diabetes suggests ACE2 involvement in diabetic nephrology. To …
models and patients with diabetes suggests ACE2 involvement in diabetic nephrology. To …
Angiotensin‑converting enzyme‑2 improves diabetic nephropathy by targeting Smad7 for ubiquitin degradation
Z Chen, X Chen, Y Bai, Z Diao… - Molecular Medicine …, 2020 - spandidos-publications.com
Abstract Angiotensin‑converting enzyme 2 (ACE2), an important component of the renin‑
angiotensin system, protects against renal tubulointerstitial fibrosis, but its level of …
angiotensin system, protects against renal tubulointerstitial fibrosis, but its level of …
Enhanced TGF-b/Smad signaling in the early stage of diabetic nephropathy is independent of the AT1a receptor
Y Okazaki, Y Yamasaki, HA Uchida, K Okamoto… - Clinical and …, 2007 - Springer
Abstract Background Angiotensin II (AII) and transforming growth factor-β (TGF-β) are
closely involved in the pathogenesis of diabetic nephropathy (DN). AII is known to induce …
closely involved in the pathogenesis of diabetic nephropathy (DN). AII is known to induce …
[HTML][HTML] Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease
Angiotensin converting enzyme (ACE) generates angiotensin II from angiotensin I, which
plays a critical role in the pathophysiology of diabetic nephropathy. However, ACE2 …
plays a critical role in the pathophysiology of diabetic nephropathy. However, ACE2 …
Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive …
Z Liu, XR Huang, HY Chen, JM Penninger… - Laboratory …, 2012 - nature.com
It is known that angiotensin (Ang)-converting enzyme (ACE) 2 catalyzes Ang II to Ang 1–7 to
prevent the detrimental effect of Ang II on blood pressure, renal fibrosis, and inflammation …
prevent the detrimental effect of Ang II on blood pressure, renal fibrosis, and inflammation …
[HTML][HTML] Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice
Type 1 diabetes is a T-cell mediated autoimmune disease characterized by pancreatic beta
cells destruction. Angiotensin-converting enzyme 2 (ACE2), a component of renin …
cells destruction. Angiotensin-converting enzyme 2 (ACE2), a component of renin …
Angiotensin-(1–7) attenuates high glucose-induced proximal tubular epithelial-to-mesenchymal transition via inhibiting ERK1/2 and p38 phosphorylation
AIMS: The kidney is an important target for both Angiotensin II and angiotensin-(1–7)[Ang-(1–
7)] in the renin–angiotensin system. However, the renal function of Ang-(1–7) remains …
7)] in the renin–angiotensin system. However, the renal function of Ang-(1–7) remains …
PERK‐Dependent Activation of the JAK2/STAT3 Pathway Contributes to High Glucose‐Induced Extracellular Matrix Deposition in Renal Tubular Epithelial Cells
Y Bao, W Liang, Y Ye, B Yi - International Journal of …, 2021 - Wiley Online Library
Background. Although the deposition of extracellular matrix (ECM) is critical leading to
tubular damage in diabetic kidney disease (DKD), the mechanism still remains unclear. The …
tubular damage in diabetic kidney disease (DKD), the mechanism still remains unclear. The …