Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation

M Marasovic, M Zocco, M Halic - Molecular cell, 2013 - cell.com
RNAi is a conserved mechanism in which small RNAs induce silencing of complementary
targets. We have previously identified priRNAs, a class of Dicer-independent small RNAs in …

[HTML][HTML] Dicer-independent primal RNAs trigger RNAi and heterochromatin formation

M Halic, D Moazed - Cell, 2010 - cell.com
Assembly of fission yeast pericentromeric heterochromatin and generation of small
interfering RNAs (siRNAs) from noncoding centromeric transcripts are mutually dependent …

Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast

F Simmer, A Buscaino, IC Kos‐Braun, A Kagansky… - EMBO …, 2010 - embopress.org
RNA interference (RNAi) is widespread in eukaryotes and regulates gene expression
transcriptionally or post‐transcriptionally. In fission yeast, RNAi is tightly coupled to template …

TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway

M Bühler, N Spies, DP Bartel, D Moazed - Nature structural & molecular …, 2008 - nature.com
In the fission yeast Schizosaccharomyces pombe, the RNA interference (RNAi) machinery is
required to generate small interfering RNAs (siRNAs) that mediate heterochromatic gene …

Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA

I Djupedal, IC Kos‐Braun, RA Mosher… - The EMBO …, 2009 - embopress.org
The formation of heterochromatin at the centromeres in fission yeast depends on
transcription of the outer repeats. These transcripts are processed into siRNAs that target …

A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA

K Kawakami, A Hayashi, J Nakayama… - Genes & …, 2012 - genesdev.cshlp.org
In fission yeast, siRNA is generated from pericentromeric noncoding RNA by the RNAi
machinery. siRNA synthesis and heterochromatin formation are interdependent, forming a …

Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi

P Pisacane, M Halic - Nature communications, 2017 - nature.com
RNAi is a conserved mechanism in which small RNAs induce silencing of complementary
targets. How Argonaute-bound small RNAs are targeted for degradation is not well …

Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi

SU Colmenares, SM Buker, M Buhler, M Dlakić… - Molecular cell, 2007 - cell.com
The fission yeast centromeric repeats are transcribed and ultimately processed into small
interfering RNAs (siRNAs) that are required for heterochromatin formation. siRNA …

RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe

A Smialowska, I Djupedal, J Wang, P Kylsten… - Biochemical and …, 2014 - Elsevier
RNA interference (RNAi) is a gene silencing mechanism conserved from fungi to mammals.
Small interfering RNAs are products and mediators of the RNAi pathway and act as …

[PDF][PDF] Common themes in siRNA-mediated epigenetic silencing pathways.

A Verdel, A Vavasseur, M Le Gorrec… - International Journal of …, 2009 - Citeseer
Small interfering RNAs (siRNAs) act through RNA interference (RNAi) pathways to silence
gene expression either at the transcriptional or post-transcriptional level. Here, we review …