Preparation of uniform-sized exenatide-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency and bio-stability

F Qi, J Wu, Q Fan, F He, G Tian, T Yang, G Ma… - Colloids and surfaces B …, 2013 - Elsevier
Exenatide-loaded poly (d, l-lactic-co-glycolic acid)(PLGA) microspheres hold great potential
as a drug delivery system to treat type 2 diabetes mellitus (T2DM) because they can …

Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification

F Qi, J Wu, T Yang, G Ma, Z Su - Acta Biomaterialia, 2014 - Elsevier
Abstract Poly (DL-lactic-co-glycolic acid)(PLGA) microspheres have been widely prepared
by many methods, including solvent evaporation, solvent extraction and the co-solvent …

Effect of stabilizers on encapsulation efficiency and release behavior of exenatide-loaded PLGA microsphere prepared by the W/O/W solvent evaporation method

H Park, DH Ha, ES Ha, JS Kim, MS Kim, SJ Hwang - Pharmaceutics, 2019 - mdpi.com
The aim of this study was to investigate the effects of various stabilizers on the encapsulation
efficiency and release of exenatide-loaded PLGA (poly (lactic-co-glycolic acid)) …

Effect of size on the in vitro/in vivo drug release and degradation of exenatide-loaded PLGA microspheres

X Lin, H Yang, L Su, Z Yang, X Tang - Journal of Drug Delivery Science and …, 2018 - Elsevier
The aim of this study was to investigate the effect of particle size on the in vitro/in vivo drug
release and degradation of macromolecule-loaded PLGA microspheres. The active …

Comparative studies on exenatide-loaded poly (D, L-lactic-co-glycolic acid) microparticles prepared by a novel ultra-fine particle processing system and spray drying

C Zhu, Y Huang, X Zhang, L Mei, X Pan, G Li… - Colloids and Surfaces B …, 2015 - Elsevier
The purpose of this study was to compare the properties of exenatide-loaded poly (d, l-lactic-
co-glycolic acid) microparticles (Ex-PLGA-MPs) prepared by a novel ultra-fine particle …

Comparative studies on the influences of primary emulsion preparation on properties of uniform-sized exenatide-loaded PLGA microspheres

F Qi, J Wu, D Hao, T Yang, Y Ren, G Ma, Z Su - Pharmaceutical research, 2014 - Springer
Purpose It is well known that primary emulsion (W 1/O) preparation process (by
ultrasonication or homogenization) plays an important role in the properties of drug-loaded …

Effects of the multilayer structures on Exenatide release and bioactivity in microsphere/thermosensitive hydrogel system

P Wang, M Jiang - Colloids and Surfaces B: Biointerfaces, 2018 - Elsevier
Traditional polypeptide-loaded PLGA microspheres (PM) using emulsion electrospray
techniques often exhibit unsteady release and limited bioactivity. To solve these two …

Formation Mechanism, In vitro and In vivo Evaluation of Dimpled Exenatide Loaded PLGA Microparticles Prepared by Ultra-Fine Particle Processing System

C Zhu, T Peng, D Huang, D Feng, X Wang, X Pan… - AAPS …, 2019 - Springer
Spherical poly (D, L-lactic-co-glycolic acid) microparticles (PLGA-MPs) have long been
investigated in order to achieve sustained delivery of proteins/peptides. However, the …

Preparation, Characterization, and Pharmacodynamics of Exenatide-Loaded Poly(DL-lactic-co-glycolic acid) Microspheres

B Liu, Q Dong, M Wang, L Shi, Y Wu, X Yu… - Chemical and …, 2010 - jstage.jst.go.jp
Exenatide (synthetic exendin-4), a 39-amino acid peptide, was encapsulated in poly (DL-
lactic-co-glycolic acid)(PLGA) microspheres as a sustained release delivery system for the …

Characterization of attributes and in vitro performance of exenatide-loaded PLGA long-acting release microspheres

T Li, A Chandrashekar, A Beig, J Walker… - European Journal of …, 2021 - Elsevier
Bydureon®(Bdn) is a once-weekly injectable long-acting release (LAR) product for adults
with type 2 diabetes based on PLGA microspheres encapsulating the glucagon like peptide …