In addition to archetypal cognitive defects, D own syndrome (DS) is characterized by altered
lymphocyte development and function, including premature thymic involution and increased …

Children with Down syndrome (DS) have low numbers of naive T cells and abnormal thymus
development and function. Because next to thymic production, peripheral proliferation …

As a result of failed induction of T cell tolerance to pancreatic B cells, non-obese diabetic
(NOD) mice develop spontaneous autoimmune insulin-dependent diabetes mellitus (IDDM) …

Thymocytes and thymic epithelial cell (TEC) cross-talk is crucial to preserve thymic
architecture and function, including maturation of TECs and dendritic cells, and induction of …

Background The function of the thymic microenvironment is to promote thymocyte
maturation, in part via regulation of thymocyte proliferation and cell death. Defects in fetal …

Nonobese diabetic (NOD) mice spontaneously develop diabetes, an auto-immune disease
characterized by the destruction of insulin-secreting [B-cells by autoreactive T cells. Defects …

Studying the molecular and genetic bases of primary immunodeficiency is valuable at
several levels. First, such information directly benefits patients in both short‐and long‐term …

Primary immunodeficiencies (PIDs) are disorders of the immune system, which lead to
increased susceptibility to infections. T‐cell defects, which may affect T‐cell …

Abstract Aims: Down Syndrome (DS), a genetic disease caused by a triplication of
chromosome 21, is characterized by increased markers of oxidative stress. In addition to …

Down syndrome (DS) thymocytes have a markedly diminished proportion of cells expressing
high levels of the α, β T cell receptor (TCRα, β) and the associated CD3 molecule. Thus, we …