A clinical model for identifying radiosensitive tumor genotypes in non–small cell lung cancer

KL Johung, X Yao, F Li, JB Yu, SN Gettinger… - Clinical Cancer …, 2013 - AACR
Purpose: Non–small cell lung cancer (NSCLC) includes a spectrum of radiosensitive and
radioresistant tumors. However, little is known about the molecular determinants of cellular …

Does lung cancer mutation status and targeted therapy predict for outcomes and local control in the setting of brain metastases treated with radiation?

TJC Wang, S Saad, YH Qureshi, A Jani… - Neuro …, 2015 - academic.oup.com
Background We investigated effects of genetic alterations in epidermal growth factor
receptor (EGFR), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma viral …

Significance of targeted therapy and genetic alterations in EGFR, ALK, or KRAS on survival in patients with non–small cell lung cancer treated with radiotherapy for …

KS Mak, JF Gainor, A Niemierko, KS Oh… - Neuro …, 2015 - academic.oup.com
Background We determined the impact of genetic alterations in EGFR, ALK, or KRAS on
survival after radiotherapy for brain metastases in non–small cell lung cancer (NSCLC) …

[HTML][HTML] EGFR mutant locally advanced non-small cell lung cancer is at increased risk of brain metastasis

D Mitra, YH Chen, R Li, G Hermann, K Atkins… - Clinical and …, 2019 - Elsevier
Background and purpose Small studies of primarily metastatic non-small cell lung cancer
(NSCLC) have suggested an association between EGFR mutation (EGFR+) and likelihood …

[HTML][HTML] Impact of EGFR mutation and ALK translocation on recurrence pattern after definitive chemoradiotherapy for inoperable stage III non-squamous non–small …

M Nakamura, S Kageyama, S Niho, M Okumura… - Clinical Lung Cancer, 2019 - Elsevier
Introduction This study was aimed at clarifying the failure pattern after definitive
chemoradiotherapy in patients with stage III non–small-cell lung cancer (NSCLC) harboring …

EGFR mutations are associated with favorable intracranial response and progression-free survival following brain irradiation in non-small cell lung cancer patients …

HL Lee, TS Chung, LL Ting, JT Tsai, SW Chen… - Radiation …, 2012 - Springer
Background The presence of epidermal growth factor receptor (EGFR) mutations in non-
small cell lung cancer (NSCLC) is associated with increased radiosensitivity in vitro …

Epidermal growth factor receptor mutations: association with favorable local tumor control following Gamma Knife radiosurgery in patients with non–small cell lung …

CC Lee, SPC Hsu, CJ Lin, HM Wu, YW Chen… - Journal of …, 2019 - thejns.org
OBJECTIVE The presence of epidermal growth factor receptor (EGFR) mutations in non–
small cell lung cancer (NSCLC) has been associated with elevated radiosensitivity in vitro …

Clinical outcomes of thoracic radiotherapy for locally advanced NSCLC with EGFR mutations or EML4-ALK rearrangement

H Hayashi, I Okamoto, H Kimura, K Sakai… - Anticancer …, 2012 - ar.iiarjournals.org
Background: Little is known about the occurrence and consequences of epidermal growth
factor receptor gene (EGFR) mutations and the fusion of the echinoderm microtubule …

Impact of EGFR Mutations and KRAS Amino Acid Substitution on the Response to Radiotherapy for Brain Metastasis of Non-Small-Cell Lung Cancer

S Renaud, M Schaeffer, AC Voegeli, M Legrain… - Future …, 2016 - Taylor & Francis
Background: Our study aimed to evaluate response rate (RR) to brain metastasis
radiotherapy (RT), depending on the genomic status of non-small-cell lung cancer. Material …

The impact of tumor biology on survival and response to radiation therapy among patients with non–small cell lung cancer brain metastases

JA Miller, R Kotecha, MS Ahluwalia… - Practical radiation …, 2017 - Elsevier
Purpose To investigate the natural history and response to radiation therapy among ALK-
rearranged, EGFR-mutated, wild-type adenocarcinoma, and squamous cell non–small cell …