Obesity in humans is often associated with metabolic inflexibility, but the underlying
molecular mechanisms remain incompletely understood. The aim of the present study was …

Aims Although the benefits of exercise can be potentiated by fasting in healthy subjects, few
studies evaluated the effects of this intervention on the metabolism of obese subjects. This …

During fasting, rapid metabolic adaptations are required to maintain energy homeostasis.
This occurs by a coordinated regulation of energy/nutrient-sensing pathways leading to …

Objective: Skeletal muscle AMP-activated protein kinase (AMPK) α2 activity is impaired in
obese, insulin-resistant individuals during exercise. We determined whether this defect …

Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …

Activation of adenosine monophosphate-activated protein kinase (AMPK) plays a central
role in allowing cells to adapt to nutrient deprivation in vitro. This link between AMPK activity …

The protein complex AMP-activated protein kinase (AMPK) is believed to play an important
role in the regulation of skeletal muscle glucose and lipid metabolism. Defects in the AMPK …

Acute or chronic activation of AMP-activated protein kinase (AMPK) increases insulin
sensitivity. Conversely, reduced expression and/or function of AMPK might play a role in …

AMPK is an evolutionary conserved sensor of cellular energy status that is activated during
exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation …

Adenosine monophosphate-activated protein kinase (AMPK), silent mating type information
regulation 2 homologue 1 (SIRT 1), and peroxisome proliferator-activated receptor γ co …