Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …

Influencing cell behavior from proliferation to differentiation using substrate or implant
topography is an attractive strategy for regenerative medicine applications. Substrate …

Nanotopography presents an effective physical approach for biomaterial cell manipulation
mediated through material-extracellular matrix interactions. The extracellular matrix that …

Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

The interaction of mammalian cells with nanoscale topography has proven to be an
important signaling modality in controlling cell function. Naturally occurring nanotopographic …

Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

This review discusses the roles in signaling to cells by nanochemical, nanostructural
(nanotopography) and mechanical means, as well as recent work and trends in …

Inspired by ultrastructural analysis of ex vivo human tissues as well as the physiological
importance of structural density, we fabricated nanogrooves with 1: 1, 1: 3 and 1: 5 spacing …

Cells interact with the surrounding environment by making tens to hundreds of thousands of
nanoscale interactions with extracellular signals and features. The goal of nanoscale tissue …

The primary aim in tissue engineering is to repair, replace, and regenerate dysfunctional
tissues to restore homeostasis. Cell delivery for repair and regeneration is gaining impetus …