Palatogenesis is a complex process implying growth, elevation and fusion of the two lateral
palatal shelves during embryogenesis. This process is tightly controlled by genetic and …

Cleft palate, including submucous cleft palate, is among the most common birth defects in
humans. While overt cleft palate results from defects in growth or fusion of the developing …

Background The palate is differently regulated and developed along the anterior-posterior
axis. The Bmp signal pathway plays a crucial role in palatogenesis. Conditioned-inactivation …

Previous work suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct
from isolated cleft secondary palate (CP). Mutations in the Bmp target gene Msx1 in families …

The molecular mechanisms by which the primordia of the midface grow and fuse to form the
primary palate portion of the craniofacial region are not well characterized. This is in spite of …

Sequential and reciprocal epithelial–mesenchymal interactions govern the development of
most tissues and organs of the craniofacial region. Bone morphogenetic proteins (BMPs) are …

Cleft palate, the most frequent congenital craniofacial birth defects in humans, arises from
genetic or environmental perturbations in the multi-step process of palate development …

As the major receptor mediated BMP signaling in craniofacial development, Bmpr1a
expression was detected in the anterior palatal shelves from E13. 5 and the posterior palatal …

The first branchial arch (BA1), which is derived from cranial neural crest (CNC) cells, gives
rise to various orofacial tissues. Cre mice are widely used for the determination of CNC and …

Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are severe disruptions
affecting orofacial structures. Patients with orofacial clefts require complex interdisciplinary …