Within 2–3 days of starvation, pronounced insulin resistance develops, possibly mediated by
increased lipid load. Here, we show that one exercise bout increases mitochondrial fatty …

Context: Both training and normal body mass index are associated with high insulin
sensitivity, but the mechanism may be different. Objective: The aim of the study was to …

Acute exercise can reverse muscle insulin resistance, but the mechanism (s) of action are
unknown. With the use of a hindlimb perfusion model, we have found that acute contraction …

We hypothesized that acute lipid-induced insulin resistance would be attenuated in high-
oxidative muscle of lean trained (LT) endurance athletes due to their enhanced metabolic …

OBJECTIVE Type 2 diabetes and insulin resistance have been associated with
mitochondrial dysfunction, but it is debated whether this is a primary factor in the …

Reductions in mitochondrial function have been proposed to cause insulin resistance,
however the possibility that impairments in insulin signaling negatively affects mitochondrial …

Fat accumulation in skeletal muscle combined with low mitochondrial oxidative capacity is
associated with insulin resistance (IR). Endurance-trained athletes, characterized by a high …

Acute physical exercise enhances insulin sensitivity in healthy subjects. We examined the
effect of a 42-km marathon run on insulin sensitivity and lipid oxidation in 19 male runners …

Type 1 and type 2 diabetes are both tightly associated with impaired glucose control.
Although both pathologies stem from different mechanisms, a reduction in insulin action …

It has long been known that acute exercise can dramatically improve insulin sensitivity in
previously insulin-resistant muscle; however, the precise mechanisms underlying this …