We have demonstrated that the activation of P2X3 receptor on peripheral afferent neurons is
critical to development of inflammatory hyperalgesia in peripheral tissue, although …

P2X7 receptors play an important role in inflammatory hyperalgesia, but the mechanisms
involved in their hyperalgesic role are not completely understood. In this study, we …

Activation of P2X7 receptors by endogenous ATP contributes to the development of
inflammatory hyperalgesia. Given the clinical importance of mechanical hyperalgesia in …

Activation of peripheral P2X3 and P2X2/3 receptors by endogenous ATP is essential to the
development of inflammatory hyperalgesia. We have previously demonstrated that this …

Abstract Activation of P2X3, 2/3 receptors by endogenous ATP contributes to the
development of inflammatory hyperalgesia. Given the clinical importance of mechanical …

Recent evidence suggests that P2X3 receptors express abundantly in nociceptive sensory
neurons and play an important role in neuropathic pain. Upregulation of prostaglandin E2 …

ATP-gated P2X receptors in nociceptive sensory neurons participate in transmission of pain
signals from the periphery to the spinal cord. To determine the role of P2X receptors under …

The mechanism of mechanical hyperalgesia in inflammation might involve a
'mechanochemical'process whereby stretch evokes the release of adenosine 5 …

Background and purpose: Protein kinase (PK) A and the ε isoform of PKC (PKCε) are
involved in the development of hypernociception (increased sensitivity to noxious or …

Prostaglandin E2 (PGE2) is a key mediator of inflammation and contributes to pain
hypersensitivity by promoting sensory neurons hyperexcitability. PGE2 synthesis results …