The counter-regulatory axis of the renin–angiotensin system (RAS) is a novel therapeutic
target in cardiovascular disease. Pathophysiological effects mediated via angiotensin II (Ang …

Chronic RAS (renin–angiotensin system) activation by both AngII (angiotensin II) and
aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro …

The renin-angiotensin-system (RAS) is a cascade of enzymatic reactions resulting ultimately
in the formation of angiotensin II. Recent research has expanded the knowledge about the …

Cardiovascular disease is America's leading health problem and the leading cause of death.
One person in three suffers from some form of cardiovascular disease. There is an urgent …

Despite the tremendous success obtained using the current pharmacotherapy, especially
angiotensin (Ang)-converting enzyme (ACE) inhibitors (ACEis) and Ang II receptor blockers …

The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

The identification of novel biochemical components of the renin–angiotensin system (RAS)
has added a further layer of complexity to the classical concept of this cardiovascular …

The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and
homeostasis due to its influence on the regulation of electrolyte balance, blood pressure …

Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …

The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure via peripheral and central mechanisms. Dysregulation of the …