The nurd architecture

HF Allen, PA Wade, TG Kutateladze - Cellular and Molecular Life Sciences, 2013 - Springer
The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin
organization, gene transcription, genomic stability and developmental signaling. NuRD has …

[HTML][HTML] The nucleosome remodeling and deacetylase complex NuRD is built from preformed catalytically active sub-modules

W Zhang, A Aubert, JMG de Segura… - Journal of molecular …, 2016 - Elsevier
The nucleosome remodeling deacetylase (NuRD) complex is a highly conserved regulator
of chromatin structure and transcription. Structural studies have shed light on this and other …

The nucleosome remodeling and deacetylase complex in development and disease

J Basta, M Rauchman - Translating epigenetics to the clinic, 2017 - Elsevier
Abstract The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the
major chromatin remodeling complexes found in cells. It plays an important role in regulating …

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

Y Zhang, HH Ng, H Erdjument-Bromage… - Genes & …, 1999 - genesdev.cshlp.org
ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation
represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex …

The NuRD complex: linking histone modification to nucleosome remodeling

Q Feng, Y Zhang - Protein Complexes that Modify Chromatin, 2003 - Springer
ATP-dependent nucleosome remodeling and core histone tail modifications play important
roles in chromatin function. Purification and characterization of the NuRD/Mi-2 complex …

Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex

SSM Alqarni, A Murthy, W Zhang, MR Przewloka… - Journal of Biological …, 2014 - ASBMB
The nucleosome remodeling and deacetylase (NuRD) complex is a widely conserved
transcriptional co-regulator that harbors both nucleosome remodeling and histone …

CHD4 is a peripheral component of the nucleosome remodeling and deacetylase complex

JKK Low, SR Webb, APG Silva, H Saathoff… - Journal of Biological …, 2016 - ASBMB
Chromatin remodeling enzymes act to dynamically regulate gene accessibility. In many
cases, these enzymes function as large multicomponent complexes that in general comprise …

The nucleosome remodeling and deacetylase complex has an asymmetric, dynamic, and modular architecture

JKK Low, APG Silva, MS Tabar, M Torrado, SR Webb… - Cell reports, 2020 - cell.com
The nucleosome remodeling and deacetylase (NuRD) complex is essential for metazoan
development but has been refractory to biochemical analysis. We present an integrated …

[HTML][HTML] The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4

AA Watson, P Mahajan, HDT Mertens, MJ Deery… - Journal of molecular …, 2012 - Elsevier
The NuRD (nucleosome remodeling and deacetylase) complex serves as a crucial
epigenetic regulator of cell differentiation, proliferation, and hematopoietic development by …

Structure and function insights into the NuRD chromatin remodeling complex

MP Torchy, A Hamiche, BP Klaholz - Cellular and Molecular Life Sciences, 2015 - Springer
Transcription regulation through chromatin compaction and decompaction is regulated
through various chromatin-remodeling complexes such as nucleosome remodeling and …