As obesity rates inexorably rise, so the incidence of diseases associated with insulin
resistance (IR) is also surging. The tendency towards obesity-associated IR appears …

Insulin resistance is observed in several diseases such as non insulin dependent diabetes
mellitus (NIDDM) or polycystic ovarian syndrome (PCOS). To understand genetic …

Abstract 'Insulin resistance'(IR) is a widely used clinical term. It is usually defined as a state
characterised by reduced glucose-lowering activity of insulin, but it is also sometimes used …

Insulin orchestrates physiological responses to ingested nutrients; however, although it
elicits widely ramifying metabolic and trophic responses from diverse tissues,'insulin …

Diabet. Med. 28, 1476–1486 (2011) Abstract Sir Harold Himsworth first observed and
articulated the phenomenon of insulin resistance in the late 1930s. Although a long delay …

Insulin resistance is a common feature of type 2 diabetes mellitus and the metabolic
syndrome, in which it is believed to be a key pathogenic factor. In such common diseases …

Insulin action starts with binding to a membrane receptor (insulin receptor-tyrosine kinase)
and with activating an insulin receptor substrate 1 (IRS-1) and substrate 2 (IRS-2). Insulin …

Insulin resistance is an essential feature of a great variety of clinical disorders, like diabetes
mellitus, obesity, essential hypertension, and is primarily due to a defect in hormone action …

Insulin resistance is among the most prevalent endocrine derangements in the world, and it
is closely associated with major diseases of global reach including diabetes mellitus …

As obesity and diabetes reach epidemic proportions in the developed world, the role of
insulin resistance and its consequences are gaining prominence. Understanding the role of …