AFP and its receptor (AFPR) are early indicators of HBx-driven hepatocarcinogenesis.
Clinical specimens, normal human liver cells L-02 and HCC cell lines were selected for …

Although tumor‐associated fetal protein AFP has demonstrated utility as a clinical tumor
marker, the significance of intracellular AFP is still unclear. The aim of this study was to …

Background: The infection of Hepatitis B virus (HBV) is closely associated with the
development of hepatocellular carcinoma (HCC), HBV-X protein (HBx) is able to induce …

Abstract Background Hepatitis B virus (HBV)-X protein (HBx) is a transactivator of host
several cellular genes including alpha-fetoprotein (AFP) and AFP receptor (AFPR) which …

A high level of serum alpha fetoprotein (AFP) is positively associated with human
hepatocellular carcinoma (HCC) carcinogenesis and metastasis; however, the function of …

Previous studies have found that alpha‐fetoprotein (AFP) can promote the proliferation of
hepatoma cells and accelerate the progression of hepatocellular carcinoma (HCC) …

AIM: To investigate the biological role of alpha fetoprotein (AFP) and its clinical significance
in carcinogenesis of hepatocellular carcinoma (HCC). METHODS: Clinical analysis of HCC …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world.
Alpha-fetoprotein (AFP) is considered as a diagnostic and prognostic tumorous marker for …

The expression of alpha-fetoprotein (AFP), a tumor-associated antigen, is silenced in normal
adult hepatocyte but reactivated in human hepatocellular carcinoma (HCC). To investigate …

The hepatitis B virus (HBV)-X protein (HBx) induces malignant transformation of liver cells,
and elevated expression of alpha-fetoprotein (AFP) is a significant biomarker of …