Epithelial-mesenchymal transition (EMT) is an important developmental process hijacked by
cancer cells for their dissemination. Here, we show that Exo70, a component of the exocyst …

Invadopodia are actin-rich membrane protrusions formed by tumor cells that degrade the
extracellular matrix for invasion. Invadopodia formation involves membrane protrusions …

Background As a key subunit of the exocyst complex, Exo70 has highly conserved
sequence and is widely found in yeast, mammals, and plants. In yeast, Exo70 mediates the …

Directional cell migration requires the coordination of actin assembly and membrane
remodeling. The exocyst is an octameric protein complex essential for exocytosis and …

Growing evidence points to exosomes as key mediators of cell–cell communication, by
transferring their specific cargo (eg, proteins, lipids, DNA and RNA molecules) from …

Metastasis in cancer consists of multiple steps, including epithelial–mesenchymal-transition
(EMT), which is characterized by the loss of epithelial-like characteristics and the gain of …

The exocyst is a multiprotein complex essential for exocytosis and plasma membrane
remodeling. The assembly of the exocyst complex mediates the tethering of post-Golgi …

Epithelial–mesenchymal transition (EMT) is a highly conserved process defined by the loss
of epithelial characteristics, and acquisition of the mesenchymal phenotype. In addition to its …

The exocyst is a multiprotein complex essential for tethering secretory vesicles to specific
domains of the plasma membrane for exocytosis,,. Here, we report that the exocyst …

The exocyst complex mediates the tethering of secretory vesicles to the plasma membrane
before SNARE-mediated membrane fusion. Recent studies have implicated the exocyst in a …