Maternal obesity caused by overnutrition exposure leads to reversal learning deficits and striatal disturbance in rats
Maternal obesity caused by overnutrition during pregnancy increases susceptibility to
metabolic risks in adulthood, such as obesity, insulin resistance, and type 2 diabetes; …
metabolic risks in adulthood, such as obesity, insulin resistance, and type 2 diabetes; …
A mouse model of pre-pregnancy maternal obesity combined with offspring exposure to a high-fat diet resulted in cognitive impairment in male offspring
C Zhu, TL Han, Y Zhao, X Zhou, X Mao, H Qi… - Experimental Cell …, 2018 - Elsevier
Background Cognitive impairment is a brain dysfunction characterized by
neuropsychological deficits in attention, working memory, and executive function. Maternal …
neuropsychological deficits in attention, working memory, and executive function. Maternal …
Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood
D Kulhanek, JE Abrahante Llorens… - American Journal …, 2022 - journals.physiology.org
Maternal obesity is exceedingly common and strongly linked to offspring obesity and
metabolic disease. Hypothalamic function is critical to obesity development. Hypothalamic …
metabolic disease. Hypothalamic function is critical to obesity development. Hypothalamic …
Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice
C Wolfrum, D Peleg-Raibstein - Nutritional neuroscience, 2019 - Taylor & Francis
Objectives: Epidemiological studies have linked maternal obesity with metabolic as well as
psychiatric disorders in the progeny. However, very little is known how maternal …
psychiatric disorders in the progeny. However, very little is known how maternal …
The influence of maternal metabolic state and nutrition on offspring neurobehavioral development: a focus on preclinical models
AJ Mitchell, GA Dunn, EL Sullivan - Biological Psychiatry: Cognitive …, 2022 - Elsevier
The prevalence of both obesity and neurodevelopmental disorders has increased
substantially over the last several decades. Early environmental factors, including maternal …
substantially over the last several decades. Early environmental factors, including maternal …
Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition
R Barra, C Morgan, P Sáez-Briones… - Nutrition …, 2019 - academic.oup.com
Studies in rats have shown that a decrease in either protein content or total dietary calories
results in molecular, structural, and functional changes in the cerebral cortex and …
results in molecular, structural, and functional changes in the cerebral cortex and …
Adult rats sired by obese fathers present learning deficits associated with epigenetic and neurochemical alterations linked to impaired brain glutamatergic signaling
CE Mezo‐González, JA García‐Santillán… - Acta …, 2024 - Wiley Online Library
Aim Offspring of obese mothers are at high risk of developing metabolic syndrome and
cognitive disabilities. Impaired metabolism has also been reported in the offspring of obese …
cognitive disabilities. Impaired metabolism has also been reported in the offspring of obese …
Maternal overnutrition induces long-term cognitive deficits across several generations
G Sarker, D Peleg-Raibstein - Nutrients, 2018 - mdpi.com
Ample evidence from epidemiological studies has linked maternal obesity with metabolic
disorders such as obesity, cardiovascular disease, and diabetes in the next generation …
disorders such as obesity, cardiovascular disease, and diabetes in the next generation …
Intergenerational transmission of the effects of maternal exposure to childhood maltreatment on offspring obesity risk: A fetal programming perspective
Childhood obesity constitutes a major global public health challenge. A substantial body of
evidence suggests that conditions and states experienced by the embryo/fetus in utero can …
evidence suggests that conditions and states experienced by the embryo/fetus in utero can …
Early life origins of metabolic disease: developmental programming of hypothalamic pathways controlling energy homeostasis
A wealth of animal and human studies demonstrate that perinatal exposure to adverse
metabolic conditions–be it maternal obesity, diabetes or under-nutrition–results in …
metabolic conditions–be it maternal obesity, diabetes or under-nutrition–results in …