Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL
A Van der Veer, E Waanders, R Pieters… - Blood, The Journal …, 2013 - ashpublications.org
Most relapses in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are
not predicted using current prognostic features. Here, we determined the co-occurrence and …
not predicted using current prognostic features. Here, we determined the co-occurrence and …
Outcomes of Children With BCR-ABL1–Like Acute Lymphoblastic Leukemia Treated With Risk-Directed Therapy Based on the Levels of Minimal Residual Disease
KG Roberts, D Pei, D Campana… - Journal of Clinical …, 2014 - ascopubs.org
Purpose BCR-ABL1–like acute lymphoblastic leukemia (ALL) is a recently identified B-cell
ALL (B-ALL) subtype with poor outcome that exhibits a gene expression profile similar to …
ALL (B-ALL) subtype with poor outcome that exhibits a gene expression profile similar to …
[HTML][HTML] Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates
JM Boer, JE Koenders, B van der Holt, C Exalto… - …, 2015 - ncbi.nlm.nih.gov
CR: complete response; SCT: stem cell transplantation. aRemaining BCP-ALL group
contains eight cases with high-hyperdiploidy (50-62 chromosomes), three TCF3-PBX1 …
contains eight cases with high-hyperdiploidy (50-62 chromosomes), three TCF3-PBX1 …
IKZF1 status as a prognostic feature in BCR-ABL1–positive childhood ALL
A Van Der Veer, M Zaliova, F Mottadelli… - Blood, The Journal …, 2014 - ashpublications.org
Childhood BCR-ABL1–positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
has an unfavorable outcome and shows high frequency of IKZF1 deletions. The prognostic …
has an unfavorable outcome and shows high frequency of IKZF1 deletions. The prognostic …
Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group Study
IM Chen, RC Harvey, CG Mullighan… - Blood, The Journal …, 2012 - ashpublications.org
As controversy exists regarding the prognostic significance of genomic rearrangements of
CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as …
CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as …
Minimal residual disease in BCR:: ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease
J Zuna, L Hovorkova, J Krotka, A Koehrmann… - Leukemia, 2022 - nature.com
Recently, we defined “CML-like” subtype of BCR:: ABL1-positive acute lymphoblastic
leukemia (ALL), resembling lymphoid blast crisis of chronic myeloid leukemia (CML). Here …
leukemia (ALL), resembling lymphoid blast crisis of chronic myeloid leukemia (CML). Here …
[HTML][HTML] BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures
JM Boer, JRM Marchante, WE Evans… - …, 2015 - ncbi.nlm.nih.gov
Patients with pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with the
BCR-ABL1 fusion gene form a small, high-risk group with a poor prognosis. 1 Approximately …
BCR-ABL1 fusion gene form a small, high-risk group with a poor prognosis. 1 Approximately …
Molecular classification improves risk assessment in adult BCR-ABL1–negative B-ALL
E Paietta, KG Roberts, V Wang, Z Gu… - Blood, The Journal …, 2021 - ashpublications.org
Genomic classification has improved risk assignment of pediatric, but not adult B-lineage
acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (# …
acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (# …
IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR‐ABL1‐negative high‐risk B‐cell precursor acute lymphoblastic leukemia
Y Yamashita, A Shimada, T Yamada… - Pediatric Blood & …, 2013 - Wiley Online Library
Background Genome‐wide analysis studies have demonstrated that IKZF1, CRLF2, and
JAK2 gene alterations correlate with poor prognosis in pediatric B‐cell precursor acute …
JAK2 gene alterations correlate with poor prognosis in pediatric B‐cell precursor acute …
IKZF1plus Defines a New Minimal Residual Disease–Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia
M Stanulla, E Dagdan, M Zaliova, A Möricke… - Journal of Clinical …, 2018 - ascopubs.org
Purpose Somatic deletions that affect the lymphoid transcription factor–coding gene IKZF1
have previously been reported as independently associated with a poor prognosis in …
have previously been reported as independently associated with a poor prognosis in …
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