Heteromeric assembly of P2X subunits
A Saul, R Hausmann, A Kless, A Nicke - Frontiers in cellular …, 2013 - frontiersin.org
Transcripts and/or proteins of P2X receptor (P2XR) subunits have been found in virtually all
mammalian tissues. Generally more than one of the seven known P2X subunits have been …
mammalian tissues. Generally more than one of the seven known P2X subunits have been …
Homotrimeric complexes are the dominant assembly state of native P2X7 subunits
A Nicke - Biochemical and biophysical research communications, 2008 - Elsevier
P2X receptors (P2XRs) are trimeric ATP-gated cation channels. Seven subunits have been
cloned. P2X4 and P2X7 subunits show overlapping expression and both subunits are …
cloned. P2X4 and P2X7 subunits show overlapping expression and both subunits are …
Biochemical and functional evidence for heteromeric assembly of P2X1 and P2X4 subunits
P2X receptors are ligand‐gated ion channels activated by extracellular ATP. In expression
systems, P2X subunits form homo‐and heterotrimeric receptors. Heteromerization is also …
systems, P2X subunits form homo‐and heterotrimeric receptors. Heteromerization is also …
Molecular and functional properties of P2X receptors—recent progress and persisting challenges
K Kaczmarek-Hájek, É Lörinczi, R Hausmann… - Purinergic …, 2012 - Springer
Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
Hetero-oligomeric assembly of P2X receptor subunits: specificities exist with regard to possible partners
P2X receptors are a distinct family of ligand-gated ion channels activated by extracellular
ATP. Each of the seven identified subunit proteins (P2X 1 through P2X 7) has been reported …
ATP. Each of the seven identified subunit proteins (P2X 1 through P2X 7) has been reported …
P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate
W Duckwitz, R Hausmann, A Aschrafi… - Journal of Biological …, 2006 - ASBMB
Functional homomeric and heteromeric ATP-gated P2X receptor channels have been
shown to display a characteristic trimeric architecture. Of the seven different isoforms …
shown to display a characteristic trimeric architecture. Of the seven different isoforms …
Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor
WJ Wilkinson, LH Jiang, A Surprenant, RA North - Molecular pharmacology, 2006 - ASPET
Lysine residues near each end of the receptor ectodomain (in rat P2X2 Lys69 and Lys308)
have been implicated in ATP binding to P2X receptors. We recorded membrane currents …
have been implicated in ATP binding to P2X receptors. We recorded membrane currents …
Coexpression of P2X3 and P2X2 receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist …
M Liu, BF King, PM Dunn, W Rong… - … of Pharmacology and …, 2001 - ASPET
Using voltage-clamp procedures on Xenopus oocytes, agonist-evoked ionic currents by P2X
receptors resulting from the coexpression of P2X2 and P2X3 subunits were compared …
receptors resulting from the coexpression of P2X2 and P2X3 subunits were compared …
Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor
B Marquez-Klaka, J Rettinger, Y Bhargava… - Journal of …, 2007 - Soc Neuroscience
P2X receptors are ATP-gated nonselective cation channels. Functional receptors are
assembled as homotrimers or heterotrimers of seven cloned subunits. Each subunit contains …
assembled as homotrimers or heterotrimers of seven cloned subunits. Each subunit contains …
P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties
V Compan, L Ulmann, O Stelmashenko… - Journal of …, 2012 - Soc Neuroscience
Ligand-gated ion channels are prototypic oligomeric membrane proteins whose
stoichiometry determines their functional properties and subcellular localization …
stoichiometry determines their functional properties and subcellular localization …