Transcripts and/or proteins of P2X receptor (P2XR) subunits have been found in virtually all
mammalian tissues. Generally more than one of the seven known P2X subunits have been …

P2X receptors (P2XRs) are trimeric ATP-gated cation channels. Seven subunits have been
cloned. P2X4 and P2X7 subunits show overlapping expression and both subunits are …

P2X receptors are ligand‐gated ion channels activated by extracellular ATP. In expression
systems, P2X subunits form homo‐and heterotrimeric receptors. Heteromerization is also …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

P2X receptors are a distinct family of ligand-gated ion channels activated by extracellular
ATP. Each of the seven identified subunit proteins (P2X 1 through P2X 7) has been reported …

Functional homomeric and heteromeric ATP-gated P2X receptor channels have been
shown to display a characteristic trimeric architecture. Of the seven different isoforms …

Lysine residues near each end of the receptor ectodomain (in rat P2X2 Lys69 and Lys308)
have been implicated in ATP binding to P2X receptors. We recorded membrane currents …

Using voltage-clamp procedures on Xenopus oocytes, agonist-evoked ionic currents by P2X
receptors resulting from the coexpression of P2X2 and P2X3 subunits were compared …

P2X receptors are ATP-gated nonselective cation channels. Functional receptors are
assembled as homotrimers or heterotrimers of seven cloned subunits. Each subunit contains …

Ligand-gated ion channels are prototypic oligomeric membrane proteins whose
stoichiometry determines their functional properties and subcellular localization …