[HTML][HTML] Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial …

JF Brothers, K Hijazi, C Mascaux, RA El-Zein, MR Spitz… - BMC medicine, 2013 - Springer
Lung cancer is the leading cause of cancer death worldwide in part due to our inability to
identify which smokers are at highest risk and the lack of effective tools to detect the disease …

[HTML][HTML] Biomarkers of risk to develop lung cancer in the new screening era

T Atwater, PP Massion - Annals of Translational Medicine, 2016 - ncbi.nlm.nih.gov
Low-dose computed tomography for high-risk individuals has for the first time demonstrated
unequivocally that early detection save lives. The currently accepted screening strategy …

Translating the transcriptome into tools for the early detection and prevention of lung cancer

YB Gesthalter, J Vick, K Steiling, A Spira - Thorax, 2015 - thorax.bmj.com
Despite advances in the management of lung cancer, this disease remains a significant
global health burden with survival rates that have not significantly improved in decades. The …

Lung cancer screening: utility of molecular applications in conjunction with low-dose computed tomography guidelines

JF Palma, P Das, O Liesenfeld - Expert review of molecular …, 2016 - Taylor & Francis
Finding early-stage lung cancer where there is a higher chance for patient survival remains
a major healthcare challenge. Low-dose spiral computed tomography for high-risk patients …

Lung cancer screening beyond low-dose computed tomography: the role of novel biomarkers

N Hasan, R Kumar, MS Kavuru - Lung, 2014 - Springer
Lung cancer is the most common and lethal malignancy in the world. The landmark National
lung screening trial (NLST) showed a 20% relative reduction in mortality in high-risk …

Lung cancer: a brief review of epidemiology and screening

C Gouvinhas, RA De Mello, D Oliveira… - Future …, 2018 - Taylor & Francis
The global burden of lung cancer has been increasing over the past years, and is still a
major threat to public health worldwide, leading to disabilities and premature mortality …

Biomarkers in lung cancer

CR Sears, PJ Mazzone - Clinics in Chest Medicine, 2020 - chestmed.theclinics.com
Lung cancer is diagnosed in more than 1.8 million people yearly and remains the leading
cause of cancer deaths in both developing and developed countries, with survival at 5 years …

[HTML][HTML] Biomarkers in lung cancer screening: achievements, promises, and challenges

LM Seijo, N Peled, D Ajona, M Boeri, JK Field… - Journal of Thoracic …, 2019 - Elsevier
The present review is an update of the research and development efforts regarding the use
of molecular biomarkers in the lung cancer screening setting. The two main unmet clinical …

[HTML][HTML] Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention

H Kathuria, Y Gesthalter, A Spira, JS Brody, K Steiling - Cancers, 2014 - mdpi.com
Lung cancer remains the leading cause of cancer-related death in the United States.
Cigarette smoking is a well-recognized risk factor for lung cancer, and a sustained elevation …

[HTML][HTML] Lung cancer screening: from imaging to biomarker

D Xiang, B Zhang, D Doll, K Shen, G Kloecker… - Biomarker …, 2013 - Springer
Despite several decades of intensive effort to improve the imaging techniques for lung
cancer diagnosis and treatment, primary lung cancer is still the number one cause of cancer …