Objective: Atelectasis and surfactant depletion may contribute to greater distension—and
thereby injury—of aerated lung regions; recruitment of atelectatic lung may protect these …

Objective: To test the hypothesis that continuous negative abdominal pressure using an iron
lung would augment positive end-expiratory pressure in recruiting atelectatic lung. Methods …

Background: Ventilator-induced lung injury occurs due to exaggerated local stresses,
repeated collapse, and opening of terminal air spaces in poorly aerated dependent lung …

Rationale: Many authors have suggested that the mechanism by which atelectasis
contributes to injury is through the repetitive opening and closing of distal airways in lung …

Utility of deadspace and capnometry measurements in determin... : Critical Care Medicine
Utility of deadspace and capnometry measurements in determination of surfactant efficacy in …

The aim of this study was to assess positive end-expiratory pressure (PEEP)-induced lung
overdistension and alveolar recruitment in six patients with acute lung injury (ALI) using a …

Objectives: Determine the intra-tidal regional gas and blood volume distributions at different
levels of atelectasis in experimental lung injury. Test the hypotheses that pulmonary aeration …

Objective: To evaluate whether mechanical ventilation using" the open lung concept" during
surfactant depletion can attenuate the deterioration in pulmonary function. Design …

Objective We utilized in vivo microscopy to measure the impact of increasing tidal volume on
individual alveolar mechanics (ie, the dynamic change in alveolar size during tidal …

Objective To test the hypothesis that the lung injury induced by certain mechanical
ventilation strategies is associated with changes in the pulmonary surfactant system. Design …