Connexin43 (Cx43) is the most abundant gap junction protein expressed in bone cells and
plays a central role in cell-to-cell communication in the skeleton. Findings of the last decade …

The role of gap junctions, particularly that of connexin43 (Cx43), has become an area of
increasing interest in bone physiology. An abundance of studies have shown that Cx43 …

The skeleton adapts to mechanical loading to promote bone formation and remodeling.
While most bone cells are involved in mechanosensing, it is well accepted that osteocytes …

Osteoblasts, osteocytes, and osteoprogenitor cells are interconnected into a functional
network by gap junctions formed primarily by connexin43 (Cx43). Over the past two …

Cell function and survival are controlled by intracellular signals, and modulated by
surrounding cells and the extracellular environment. Connexin channels participate in these …

Shaping of the skeleton (modeling) and its maintenance throughout life (remodeling) require
coordinated activity among bone forming (osteoblasts) and resorbing cells (osteoclasts) and …

Connexin (Cx) 43 serves important roles in bone function and development. Targeted
deletion of Cx43 in osteoblasts or osteocytes leads to increased osteocyte apoptosis …

Abstract Connexin43 (Cx43) containing gap junctions play an important role in bone
homeostasis, yet little is known about the second messengers communicated by Cx43 …

The cytoplasmic C‐terminus of connexin43 (Cx43) interacts with numerous signaling
complexes. We hypothesize that signal complex docking to the Cx43 C‐terminus (CT) is …

Cell-to-cell and cell-to-matrix communication in bone cells mediated by gap junctions and
hemichannels, respectively, maintains bone homeostasis. Gap junctional communication …