Early life factors and type 2 diabetes mellitus

X Jiang, H Ma, Y Wang, Y Liu - Journal of diabetes research, 2013 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a multifactorial disease, and its aetiology involves a
complex interplay between genetic, epigenetic, and environmental factors. In recent years …

Early determinants of type-2 diabetes

LM Berends, SE Ozanne - Best practice & research Clinical endocrinology …, 2012 - Elsevier
The global prevalence of type-2 diabetes (T2D) has more than doubled in the last 30 years
and is predicted to continue to rise at an alarming rate. The associated health and financial …

Intra-uterine origins of type 2 diabetes

RH Jones, SE Ozanne - Archives of physiology and biochemistry, 2007 - Taylor & Francis
Epidemiological studies have linked low birth weight with an increased risk of type 2
diabetes in later life. This finding has been observed in many populations worldwide, in …

Early-life programming of type 2 diabetes mellitus: understanding the association between epigenetics/genetics and environmental factors

FZ Kadayifci, S Haggard, S Jeon, K Ranard… - Current …, 2019 - ingentaconnect.com
Type 2 Diabetes Mellitus is an increasing public health problem that poses a severe social
and economic burden affecting both developed and developing countries. Defects in insulin …

Type 2 diabetes in youth: the role of early life exposures

A Rughani, JE Friedman, JB Tryggestad - Current diabetes reports, 2020 - Springer
Abstract Purpose of Review This review examines the impact of early life exposures on
glucose metabolism in the offspring and explores potential metabolic mechanisms leading …

Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes

A Vaag, C Brøns, L Gillberg, NS Hansen… - Acta obstetricia et …, 2014 - Wiley Online Library
Low birthweight (LBW) individuals and offspring of women with gestational diabetes mellitus
(GDM) exhibit increased risk of developing type 2 diabetes (T2D) and associated …

Fetal determinants of type 2 diabetes

B Reusens, SE Ozanne, C Remacle - Current drug targets, 2007 - ingentaconnect.com
Type 2 diabetes, which has dramatically increased during the last decade normally results
from a combination of pancreatic beta cell dysfunction and insulin resistance. One of the …

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

L Chen, DJ Magliano, PZ Zimmet - Nature reviews endocrinology, 2012 - nature.com
Over the past three decades, the number of people with diabetes mellitus has more than
doubled globally, making it one of the most important public health challenges to all nations …

Perinatal risk factors for diabetes in later life

M Kaijser, AK Edstedt Bonamy, O Akre… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE—Low birth weight is consistently associated with an increased risk of type 2
diabetes in adulthood, but the individual contributions from poor fetal growth and preterm …

Preterm birth and risk of type 1 and type 2 diabetes: a national cohort study

C Crump, J Sundquist, K Sundquist - Diabetologia, 2020 - Springer
Aims/hypothesis Preterm birth (gestational age< 37 weeks) has been associated with insulin
resistance early in life. However, no large population-based studies have examined risks of …