Previous studies have suggested that Bmp4 is a key Msx1-dependent mesenchymal
odontogenic signal for driving tooth morphogenesis through the bud-to-cap transition …

Mutations in MSX1 cause craniofacial developmental defects, including tooth agenesis, in
humans and mice. Previous studies suggest that Msx1 activates Bmp4 expression in the …

Bmp4 expression is tightly regulated during embryonic tooth development, with early
expression in the dental epithelial placode leading to later expression in the dental …

In the developing mammalian tooth, the cranial neural crest derived dental mesenchyme
consists of the dental papilla and dental follicle. The dental papilla gives rise to odontoblasts …

Bmp4 is a downstream gene of Msx1 in early mouse tooth development. In this study, we
introduced the Msx1-Bmp4 transgenic allele to the Msx1 mutants in which tooth …

Tooth development is regulated by a reciprocal series of epithelial-mesenchymal
interactions. Bmp4 has been identified as a candidate signalling molecule in these …

The development of many organs depends on sequential epithelial-mesenchymal
interactions, and the developing tooth germ provides a powerful model for elucidating the …

Most vertebrate organs begin their initial formation by a common, developmentally
conserved pattern of inductive tissue interactions between two tissues. The developing tooth …

Tooth development is regulated by sequential and reciprocal epithelium-mesenchymal
interactions and their related molecular signaling pathways, such as bone morphogenetic …

Formation of highly organized dental hard tissues is a complex process involving sequential
and ordered deposition of an extracellular scaffold, followed by its mineralization …