Loss of chromosomes is the primary event in near-haploid and low-hypodiploid acute lymphoblastic leukemia

S Safavi, E Forestier, I Golovleva, G Barbany, KH Nord… - Leukemia, 2013 - nature.com
Hypodiploidy (o46 chromosomes) is found in B5–8% of acute lymphoblastic leukemia (ALL).
1, 2 It may be subdivided into high hypodiploidy (40–45 chromosomes), low hypodiploidy …

[HTML][HTML] Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: when less is too much

O Molina, A Bataller, N Thampi, J Ribera, I Granada… - Cancers, 2021 - mdpi.com
Simple Summary B-cell acute lymphoblastic leukemia (B-ALL) is characterized by an
uncontrolled proliferation of blood cells in the bone marrow. A small fraction of B-ALL …

Masked hypodiploidy: hypodiploid acute lymphoblastic leukemia (ALL) mimicking hyperdiploid ALL in children: a report from the Children's Oncology Group

AJ Carroll, M Shago, FM Mikhail, SC Raimondi… - Cancer genetics, 2019 - Elsevier
Hyperdiploidy with greater than 50 chromosomes is usually associated with favorable
prognosis in pediatric acute lymphoblastic leukemia (ALL), whereas hypodiploidy with≤ 43 …

Near-haploid and low-hypodiploid acute lymphoblastic leukemia: two distinct subtypes with consistently poor prognosis

S Safavi, K Paulsson - Blood, The Journal of the American …, 2017 - ashpublications.org
Hypodiploidy< 40 chromosomes is an uncommon genetic feature of acute lymphoblastic
leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses …

[HTML][HTML] Masked Hypodiploidy: Hypodiploid Acute Lymphoblastic Leukemia (ALL) in Children Mimicking Hyperdiploid ALL: A Report From the Children's Oncology …

AJ Carroll, NA Heerema, JM Gastier-Foster, C Astbury… - Blood, 2009 - Elsevier
Abstract Abstract 1580 Poster Board I-606 Hyperdiploidy with greater than 50 chromosomes
is usually associated with a good prognosis in childhood acute lymphoblastic leukemia …

High hyperdiploid childhood acute lymphoblastic leukemia

K Paulsson, B Johansson - Genes, Chromosomes and Cancer, 2009 - Wiley Online Library
Abstract High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic
abnormality pattern in childhood B‐cell precursor acute lymphoblastic leukemia (ALL) …

Next‐generation‐sequencing‐based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic …

C Chen, C Bartenhagen, M Gombert… - Genes …, 2013 - Wiley Online Library
Abstract Near haploidy (23–29 chromosomes) is a numerical cytogenetic aberration in
childhood acute lymphoblastic leukemia (ALL) associated with particularly poor outcome. In …

Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia

CJ Harrison, AV Moorman, ZJ Broadfield… - British journal of …, 2004 - Wiley Online Library
This study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest
series of patients with hypodiploidy (< 46 chromosomes) yet reported. The incidence of 5 …

Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia

CH Pui, DL Williams, SC Raimondi, GK Rivera… - 1987 - ashpublications.org
Abstract Leukemic cells from 31 (7.6%) of 409 children with newly diagnosed acute
lymphoblastic leukemia (ALL) had a hypodiploid karyotype. The patients' ages ranged from …

[HTML][HTML] Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children

OA Haas, A Borkhardt - Leukemia, 2022 - nature.com
Hyperdiploidy is the largest genetic entity B-cell precursor acute lymphoblastic leukemia in
children. The diagnostic hallmark of its two variants that will be discussed in detail herein is …