The developmental origins of health and disease (DOHaD) is a paradigm for understanding
metabolic diseases of modern humans. Vulnerability to disease is linked to perturbations in …

The perinatal period is a sensitive time in mammalian development that can have long-
lasting consequences on offspring phenotype via maternal effects. Maternal effects have …

Abstract The literature about Developmental Origins of Health and Disease (DOHaD)
studies is considerably growing. Maternal and paternal environment, during all the …

Many biological systems have critical periods that overlap with the age of maternal
provisioning via placenta or lactation. As such, they serve as conduits for phenotypic …

Compelling epidemiological and animal experimental data demonstrate that
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …

Evolutionary maternal effects occur whenever a mother's phenotypic traits directly affect her
offspring's phenotype, independent of the offspring's genotype. Some of the phenotypic traits …

The intrauterine environment has an important influence on lifelong health, and babies who
grew poorly in the womb are more likely to develop chronic diseases in later life. Placental …

Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

The placenta is a transmitter of fetal need and fetal quality, interfacing directly with maternal
physiology and ecology. Plasticity of placental structure and function across the …

Lactation, an important characteristic of mammalian reproduction, has evolved by exploiting
a diversity of strategies across mammals. Comparative genomics and transcriptomics …