Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …

Sox proteins are found in all metazoans and are active in many developmental processes.
Their function as transcription factors is governed by their DNA-binding properties as much …

In metazoa, SOX family transcription factors play many diverse roles. In vertebrate, they are
well-known regulators of numerous developmental processes. Wide-ranging studies have …

Sox transcription factors play key regulatory roles throughout development, binding DNA
through a consensus (A/T)(A/T) CAA (A/T) G sequence. Although many different Sox …

Transcriptional regulatory functions of SOX proteins generally require the cooperation of
partner factors that bind DNA in the vicinity of the SOX site. Each SOX–partner pair selects a …

The general view of development consists of the acquisition of committed/differentiated
phenotypes following a period of self‐renewal and progenitor expansion. Lineage …

Transcription factors of the Sox family arose around the advent of multicellularity in animals,
arguing that their ability to regulate the expression of extracellular matrix, cell adhesion and …

Sox proteins belong to the HMG box superfamily of DNA-binding proteins and are found
throughout the animal kingdom. They are involved in the regulation of such diverse …

Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

SOX transcription factors perform a remarkable variety of important roles in vertebrate
development, either activating or repressing specific target genes through interaction with …