Functions of the Hha and YdgT Proteins in Transcriptional Silencing by the Nucleoid Proteins, H-NS and StpA, in Escherichia coli

T Ueda, H Takahashi, E Uyar, SHU Ishikawa… - DNA …, 2013 - academic.oup.com
Abstract The Hha and YdgT proteins are suggested to modulate the expression of
horizontally acquired genes by interacting with H-NS and StpA, which play central roles in …

Escherichia coli Histone-Like Protein H-NS Preferentially Binds to Horizontally Acquired DNA in Association with RNA Polymerase

T Oshima, S Ishikawa, K Kurokawa, H Aiba… - DNA …, 2006 - academic.oup.com
Heat-stable nucleoid-structuring protein (H-NS) is one of the main nucleoid proteins
expressed in exponentially growing Escherichia coli cells. In addition to a role in nucleoid …

Horizontally acquired homologues of the nucleoid‐associated protein H‐NS: implications for gene regulation

CJ Dorman - Molecular microbiology, 2010 - Wiley Online Library
H‐NS is one of the most intensively studied members of the family of bacterial nucleoid‐
associated proteins. It is a DNA‐binding protein with a preference for A+ T‐rich DNA …

Genomic analysis reveals epistatic silencing of “expensive” genes in Escherichia coli K-12

R Srinivasan, D Chandraprakash… - Molecular …, 2013 - pubs.rsc.org
A barrier for horizontal gene transfer is high gene expression, which is metabolically
expensive. Silencing of horizontally-acquired genes in the bacterium Escherichia coli is …

Heteromeric Interactions among Nucleoid-Associated Bacterial Proteins: Localization of StpA-Stabilizing Regions in H-NS of Escherichia coli

J Johansson, S Eriksson, B Sondén, SN Wai… - Journal of …, 2001 - Am Soc Microbiol
The nucleoid-associated proteins H-NS and StpA in Escherichia coli bind DNA as oligomers
and are implicated in gene regulatory systems. There is evidence for both homomeric and …

Probing the structure, function, and interactions of the Escherichia coli H-NS and StpA proteins by using dominant negative derivatives

RM Williams, S Rimsky, H Buc - Journal of bacteriology, 1996 - Am Soc Microbiol
Twelve different dominant negative mutants of the Escherichia coli nucleoid-associated
protein, H-NS, have been selected and characterized in vivo. The mutants are all severely …

Requirement for the molecular adapter function of StpA at the Escherichia coli bgl promoter depends upon the level of truncated H‐NS protein

A Free, ME Porter, P Deighan… - Molecular …, 2001 - Wiley Online Library
Truncated derivatives of the Escherichia coli nucleoid‐associated protein H‐NS that lack the
DNA‐binding domain remain competent for silencing of the cryptic bgl operon in vivo …

Interference of transcription across H‐NS binding sites and repression by H‐NS

AA Rangarajan, K Schnetz - Molecular Microbiology, 2018 - Wiley Online Library
Nucleoid‐associated protein H‐NS represses transcription by forming extended DNA–H‐NS
complexes. Repression by H‐NS operates mostly at the level of transcription initiation. Less …

H-NS mediates the silencing of laterally acquired genes in bacteria

S Lucchini, G Rowley, MD Goldberg, D Hurd… - PLoS …, 2006 - journals.plos.org
Histone-like nucleoid structuring protein (H-NS) is a modular protein that is associated with
the bacterial nucleoid. We used chromatin immunoprecipitation to determine the binding …

Molecular aspects of the E. coli nucleoid protein, H-NS: a central controller of gene regulatory networks

RM Williams, S Rimsky - FEMS microbiology letters, 1997 - academic.oup.com
The nucleoid-associated protein H-NS has a central role in the structuring and control of the
enteric bacterial chromosome. This protein has been demonstrated to contribute to the …