Cleft palate is one of the most common birth defects in humans. Whereas gene knockout
studies in mice have shown that both the Osr2 and Pax9 transcription factors are essential …

Cleft palate, a common congenital deformity, can arise from disruptions in any stage of
palatogenesis, including palatal shelf growth, elevation, adhesion, and fusion. Paired box …

Cleft palate is a common birth defect caused by disruption of palatogenesis during
embryonic development. Although mutations disrupting components of the Wnt signaling …

Developmental abnormalities of craniofacial structures and teeth often occur sporadically
and the underlying genetic defects are not well understood, in part due to unknown gene …

Background Despite the strides made in understanding the complex network of key
regulatory genes and cellular processes that drive palate morphogenesis, patients suffering …

Cleft palate is a common congenital birth defect in humans. In mammals, the palatal tissue
can be distinguished into anterior bony hard palate and posterior muscular soft palate that …

Pax genes have been shown to play important roles in mammalian development and
organogenesis. Pax9, a member of this transcription factor family, is expressed in somites …

Transforming growth factor-β (TGF-β3) gene disruption causes cleft secondary palate. Pax9
and Sonic hedgehog (Shh) genes are involved in the patterning of vertebrate embryonic …

Development of the mammalian secondary palate involves multiple steps of highly regulated
morphogenetic processes that are frequently disturbed during human development …

The mammalian secondary palate exhibits morphological, pathological and molecular
heterogeneity along the anteroposterior axis. Although the cell proliferation rates are similar …