The junctional adhesion molecules Jam-b and Jam-c interact together at interendothelial
junctions and have been involved in the regulation of immune response, inflammation, and …

Background The molecular mechanisms of haematopoietic stem cells (HSC) mobilization
and homing to the liver after partial hepatectomy (PH) remain largely unexplored. Methods …

We recently demonstrated that ex vivo activation of SMAD-independent bone
morphogenetic protein 4 (BMP4) signaling in hematopoietic stem/progenitor cells (HSPCs) …

Mobilization of hematopoietic stem and progenitor cells (HPCs) is induced by treatment with
granulocyte-colony stimulating factor, chemotherapy, or irradiation. We observed that these …

Cerebral ischemia is a major cause of morbidity and mortality in the aged population, as well
as a tremendous burden on the healthcare system. Despite timely treatment with …

Several intracellular pathogens, including a key etiological agent of chronic periodontitis,
Porphyromonas gingivalis, infect blood myeloid dendritic cells (mDCs). This infection results …

Preclinical studies show that stroma affects sensitivity of prostate cancer cells via activation
of the CXCR4/CXCL12 pathway. Here we studied the effect of CXCR4 inhibition combined …

Alcoholic liver disease affects a great number of people worldwide. With limited therapeutic
options, stem cell therapy offers significant potential for these patients. To date, a limited …

Biosimilars are defined as biotherapeutic drugs that have been shown to have comparable
quality, safety, and efficacy to the original product. Fuelled by the patent cliff in the next 5 …

Bone marrow is the major site of hematopoiesis in mammals. The bone marrow environment
plays an essential role in the regulation of hematopoietic stem and progenitor cells by …