Background: Indications for prophylactic implantable cardioverter-defibrillator (ICD) therapy
in patients with inherited cardiac diseases stem from observational studies and are …

Una quota non trascurabile di cardiomiopatie riconosce una base eziologica genetica.
Tuttavia non è sempre possibile correlare direttamente il fenotipo con la specifica …

Cardiomyocyte contraction is controlled by intracellular Ca 2+ concentrations. Action
potential opens the voltage-gated calcium channel in the sarcolemma and triggers the …

Phospholamban (PLN) is a 52 amino acid membrane protein found in the sarcoplasmic
reticulum (SR) of cardiac muscle. 1 PLN is a key protein in excitation-contraction coupling …

Background: The gene Coiled Coil Domain Containing 80 (Ccdc80) is widely expressed in
normal human tissues, at particularly high levels in heart, skeletal muscle and adipose …

Phospholamban (PLB) is an integral membrane protein that plays an important role in
regulation of cardiac calcium handling and contractility. PLB exists as a homopentamer in …

Submitting laboratory: Bristol RGC 1. Disorder/condition–approved name and symbol as
published on the OMIM database (alternative names will be listed on the UKGTN website) If …

Modulation of cardiac rate and contraction through calcium-dependent and independent
means are of central import to the ability of an organism to adapt to its environment. Nicotinic …

The CDC identifies heart disease as the leading cause of death in the US, and current
treatments have variable success. Gene therapy is being investigated as an additional …

The heart is composed of multiple constituent cell types; the primary cells being fibroblasts,
cardiomyocytes, endothelial and smooth muscle cells. Here, I employed membrane isolation …