Abstract When the National Institutes of Health Mouse Models of Human Cancer Consortium
initiated the Prostate Steering Committee 15 years ago, there were no genetically …

A major clinical hurdle for the management of advanced prostate cancer (PCa) in patients is
the resistance of tumors to androgen deprivation therapy (ADT) and their subsequent …

INTRODUCTION By regulating cell fate, proliferation, and survival, Notch pathway signaling
provides critical input into differentiation, organization, and function of multiple tissues. Notch …

Overexpression of the histone acetyltransferase p300 is implicated in the proliferation and
progression of prostate cancer, but evidence of a causal role is lacking. In this study, we …

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a non-redundant
lipid phosphatase that restrains and fine tunes the phosphatidylinositol-3-kinase (PI3K) …

The relevance of potentially reversible post-translational modifications required for
controlling cellular processes in cancer is one of the most thriving arenas of cellular and …

Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes,
yet little is known about its other potential target genes or its biological function. Here, we …

Genetically engineered mouse (GEM) models are a pillar of functional cancer research.
Here, we developed RapidCaP, a GEM modeling system that uses surgical injection for viral …

Although symmetrical and asymmetrical divisions of stem cells have been extensively
studied in invertebrate and mammalian neural epithelia, their role remains largely unknown …

Abstract Annexin A1 (AnxA1), a phospholipid-binding protein and regulator of glucocorticoid-
induced inflammatory signaling, has implications in cancer. Here, a role for AnxA1 in …