Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis
The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer
development are poorly understood. We identified the chromatin remodeling protein, ING4 …
development are poorly understood. We identified the chromatin remodeling protein, ING4 …
[HTML][HTML] Deletion of atbf1/zfhx3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways
The ATBF1/ZFHX3 gene at 16q22 is the second most frequently mutated gene in human
prostate cancer and has reduced expression or mislocalization in several types of human …
prostate cancer and has reduced expression or mislocalization in several types of human …
Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo
DS Ming, S Pham, S Deb, MY Chin, G Kharmate… - The Journal of steroid …, 2014 - Elsevier
Castration-resistant prostate cancer (CRPC) remains largely dependent on androgen
receptor (AR). Residual tissue androgens are consistently detected within CRPC tumors and …
receptor (AR). Residual tissue androgens are consistently detected within CRPC tumors and …
Targeting drug-resistant prostate cancer with dual PI3K/mTOR inhibition
KD Tang, MT Ling - Current medicinal chemistry, 2014 - ingentaconnect.com
The phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway is one of the most frequently
activated signaling pathways in prostate cancer cells, and loss of the tumor suppressor …
activated signaling pathways in prostate cancer cells, and loss of the tumor suppressor …
Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis
GA Bjerke, CS Yang, HF Frierson, BM Paschal… - Oncogene, 2014 - nature.com
Mutations in the PTEN tumor suppressor gene are found in a high proportion of human
prostate cancers, and in mice, Pten deletion induces high-grade prostate intraepithelial …
prostate cancers, and in mice, Pten deletion induces high-grade prostate intraepithelial …
Review of animal models of prostate cancer bone metastasis
Prostate cancer bone metastases are associated with a poor prognosis and are considered
incurable. Insight into the formation and growth of prostate cancer bone metastasis is …
incurable. Insight into the formation and growth of prostate cancer bone metastasis is …
Dependence of castration‐resistant prostate cancer (CRPC) stem cells on CRPC‐associated fibroblasts
H Adisetiyo, M Liang, CP Liao, JH Jeong… - Journal of cellular …, 2014 - Wiley Online Library
We previously established a role for cancer‐associated fibroblasts (CAF) in enhancing the
self‐renewal and differentiation potentials of putative prostate cancer stem cells (CSC). Our …
self‐renewal and differentiation potentials of putative prostate cancer stem cells (CSC). Our …
Expression of phosphorylated‐mTOR during the development of prostate cancer
SIM Sutherland, R Pe Benito, SM Henshall… - The …, 2014 - Wiley Online Library
BACKGROUND The PI3K pathway plays a significant role in the progression of prostate
cancer (PCa) to an advanced stage. Mouse models suggest that the downstream effector …
cancer (PCa) to an advanced stage. Mouse models suggest that the downstream effector …
Diarylthiohydantoin compounds
ME Jung, D Yoo, CL Sawyers, C Tran… - US Patent …, 2014 - Google Patents
US8648105B2 - Diarylthiohydantoin compounds - Google Patents US8648105B2 -
Diarylthiohydantoin compounds - Google Patents Diarylthiohydantoin compounds …
Diarylthiohydantoin compounds - Google Patents Diarylthiohydantoin compounds …
Androgen deprivation induces phenotypic plasticity and promotes resistance to molecular targeted therapy in a PTEN-deficient mouse model of prostate cancer
MA De Velasco, M Tanaka, Y Yamamoto… - …, 2014 - academic.oup.com
Castration-resistant prostate cancer is an incurable heterogeneous disease that is
characterized by a complex multistep process involving different cellular and biochemical …
characterized by a complex multistep process involving different cellular and biochemical …