Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
ME Jung, CL Sawyers, S Ouk, C Tran… - US Patent …, 2014 - Google Patents
US8802689B2 - Androgen receptor modulator for the treatment of prostate cancer and androgen
receptor-associated diseases - Google Patents US8802689B2 - Androgen receptor modulator …
receptor-associated diseases - Google Patents US8802689B2 - Androgen receptor modulator …
[HTML][HTML] Klf5 Deletion Promotes Pten Deletion–Initiated Luminal-Type Mouse Prostate Tumors through Multiple Oncogenic Signaling Pathways
Krüppel-like factor 5 (KLF5) regulates multiple biologic processes. Its function in
tumorigenesis appears contradictory though, showing both tumor suppressor and tumor …
tumorigenesis appears contradictory though, showing both tumor suppressor and tumor …
A critical role of the PTEN/PDGF signaling network for the regulation of radiosensitivity in adenocarcinoma of the prostate
M Christensen, AJ Najy, M Snyder, LS Movilla… - International Journal of …, 2014 - Elsevier
Purpose Loss or mutation of the phosphate and tensin homologue (PTEN) is a common
genetic abnormality in prostate cancer (PCa) and induces platelet-derived growth factor D …
genetic abnormality in prostate cancer (PCa) and induces platelet-derived growth factor D …
Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model
Multiple genetic alterations are associated with prostate carcinogenesis. Tumor-suppressor
genes phosphatase and tensin homolog deleted on chromosome 10 (Pten) and androgen …
genes phosphatase and tensin homolog deleted on chromosome 10 (Pten) and androgen …
Zeb1 promotes androgen independence of prostate cancer via induction of stem cell-like properties
P Li, J Wang, M Chu, K Zhang… - … biology and medicine, 2014 - journals.sagepub.com
Current androgen deprivation therapy often leads to androgen independence. However,
mechanism of the therapeutic failure is still not well understood. Here, we demonstrate …
mechanism of the therapeutic failure is still not well understood. Here, we demonstrate …
Role of PTEN in basal cell derived lung carcinogenesis
SP Malkoski, TG Cleaver, JJ Thompson… - Molecular …, 2014 - Wiley Online Library
Lung adenocarcinoma (AdC) and lung squamous cell carcinoma (SCC) are the most
common non‐small cell lung cancer (NSCLC) subtypes, however, most genetic mouse …
common non‐small cell lung cancer (NSCLC) subtypes, however, most genetic mouse …
PIP5K1α inhibition as a therapeutic strategy for prostate cancer
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
pathway is a highly conserved signaling pathway stretching from worms to humans (1). This …
pathway is a highly conserved signaling pathway stretching from worms to humans (1). This …
Tumor models for prostate cancer exemplified by fibroblast growth factor 8-induced tumorigenesis and tumor progression
J Tuomela, P Härkönen - Reproductive biology, 2014 - Elsevier
Prostate cancer is a very common malignancy among Western males. Although most tumors
are indolent and grow slowly, some grow and metastasize aggressively. Because prostate …
are indolent and grow slowly, some grow and metastasize aggressively. Because prostate …
Diarylhydantoin compounds
ME Jung, D Yoo - US Patent 8,680,291, 2014 - Google Patents
US8680291B2 - Diarylhydantoin compounds - Google Patents US8680291B2 - Diarylhydantoin
compounds - Google Patents Diarylhydantoin compounds Download PDF Info Publication …
compounds - Google Patents Diarylhydantoin compounds Download PDF Info Publication …