Primary established genetic abnormalities in B-cell precursor acute lymphoblastic leukemia
include high hyperdiploidy (51–65 chromosomes), the translocations t (12; 21)(p13; …

Abstract Background Children with Down syndrome (DS) have an increased risk for acute
lymphoblastic leukemia (ALL). Although previous studies have shown that DS-ALL differs …

Over the past decade, there has been increasing biochemical evidence that the Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is aberrantly …

In Western countries, gene alterations involving the CRLF2‐JAK signaling pathway are
identified in approximately 50–60% of patients with Down syndrome‐associated acute …

As the most lethal gynecological malignancy, ovarian cancer has attracted much attention
over the past few decades; however, the early detection of this malignancy has been largely …

Acute lymphoblastic leukemia (ALL) is the most common form of childhood malignancy.
Detecting and characterizing recurrent translocations is critical for ALL diagnosis and …

The successful therapy of childhood leukemia has been characterized by careful
personalized adaptation of therapy by risk stratification. Yet almost all drugs are relatively …

IL-7, produced by stromal cells in the thymus and other lymphoid organs, is required for
thymic development and peripheral survival of T cells. The IL-7 receptor (IL-7R) consists of 2 …

Over the past decade, there has been increasing biochemical evidence that the Janus
kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is aberrantly …

Loss of chromosome Y (LOY) in the bone marrow has long been considered as an age-
related phenomenon with an incidence of more than 25% in males beyond the age of 80 …