Interactions between commensals and the host impact the metabolic and immune status of
metazoans. Their deregulation is associated with age-related pathologies like chronic …

Background The changes that occur in the microbiome of aging individuals are unclear,
especially in light of the imperfect correlation of frailty with age. Studies in older human …

Objective The commensal microbiota, host immunity and metabolism participate in a
signalling network, with diet influencing each component of this triad. In addition to diet …

Nonalcoholic fatty liver disease (NAFLD) is common in the elderly, in whom it carries a more
substantial burden of hepatic (nonalcoholic steatohepatitis, cirrhosis and hepatocellular …

Obesity and its associated disorders are a major public health concern. Although obesity
has been mainly related with perturbations of the balance between food intake and energy …

To date, the majority of research into the human gut microbiota has focused on the bacterial
fraction of the community. Inevitably, this has resulted in a poor understanding of the …

The human gut microbiota comprises approximately 100 trillion microbial cells and has a
significant effect on many aspects of human physiology including metabolism, nutrient …

The human gut represents a highly complex ecosystem, which is densely colonized by a
myriad of microorganisms that influence the physiology, immune function and health status …

A large body of evidence suggests that the regulation of energy balance and glucose
homeostasis by fermentable carbohydrates induces specific changes in the gut microbiota …

IBS is a debilitating condition that markedly affects quality of life. The chronic nature, high
prevalence and associated comorbidities contribute to the considerable economic burden of …