The mechanistic basis of regulatory variation and the prevailing evolutionary forces shaping
that variation are known to differ between sexes and between chromosomes. Regulatory …

Allele-specific (AS) assessment of chromatin has the potential to elucidate specific cis-
regulatory mechanisms, which are predicted to underlie the majority of the known genetic …

The differential abundance of transcripts from alternative alleles of a gene, for example in a
hybrid plant or an outbred natural population, can provide information about the nature of …

The development of novel high-throughput technologies has opened up the opportunity to
deeply characterize patient tissues at various molecular levels and has given rise to a …

Identifying gene expression changes in cancer provides opportunities to identify biomarkers
that can be informative in regard to risk and in the choice of treatment options. In recent …

Advances in high-throughput genomic technology seen in recent years have enabled the
measurement of gene expression, DNA sequence polymorphisms, and epigenetic marks …

A detailed mechanistic understanding of the direct functional consequences of DNA
variation on gene regulatory mechanism is critical for a complete understanding of complex …

A new tool emerging to fine map QTL associated with treatments or conditions, such as
disease, is allele-specific expression (ASE). We used allele-specific expression (ASE) to find …

Genome-wide association studies (GWAS) have identified more than 70 loci associated with
type 2 diabetes (T2D), but for most, the underlying causal variants, associated genes, and …

Current practice in mass spectrometry-based proteomics is to identify peptides by
comparison of experimental spectra with theoretical spectra derived from a reference protein …