Placenta-specific microRNAs in exosomes–good things come in nano-packages

Y Ouyang, JF Mouillet, CB Coyne, Y Sadovsky - Placenta, 2014 - Elsevier
MicroRNAs (miRNAs) are small noncoding RNA gene products that commonly regulate
mRNA expression by repression of translation and/or transcript decay. Whereas common …

[HTML][HTML] Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128

YK Adlakha, N Saini - Molecular cancer, 2014 - Springer
MicroRNAs, the non-coding single-stranded RNA of 19–25 nucleotides are emerging as
robust players of gene regulation. Plethora of evidences support that the ability of …

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

J Ward, C Kanchagar… - Proceedings of the …, 2014 - National Acad Sciences
We have identified, by quantitative real-time PCR, hundreds of miRNAs that are dramatically
elevated in the plasma or serum of acetaminophen (APAP) overdose patients. Most of these …

Role of mi R‐155 in the regulation of lymphocyte immune function and disease

N Seddiki, V Brezar, N Ruffin, Y Lévy… - …, 2014 - Wiley Online Library
Micro RNA s (mi RNA s) have emerged as critical regulators of gene expression within cells.
One particular mi RNA, mi R‐155, is highly expressed within lymphocytes (both B and T …

PAPD5-mediated 3′ adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease

J Boele, H Persson, JW Shin, Y Ishizu… - Proceedings of the …, 2014 - National Acad Sciences
Next-generation sequencing experiments have shown that microRNAs (miRNAs) are
expressed in many different isoforms (isomiRs), whose biological relevance is often unclear …

MicroRNA in teleost fish

TT Bizuayehu, I Babiak - Genome biology and evolution, 2014 - academic.oup.com
MicroRNAs (miRNAs) are transcriptional and posttranscriptional regulators involved in
nearly all known biological processes in distant eukaryotic clades. Their discovery and …

[HTML][HTML] miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF

K Varendi, A Kumar, MA Härma… - Cellular and molecular life …, 2014 - Springer
Brain-derived neurotrophic factor (BDNF) is a secreted protein of the neurotrophin family that
regulates brain development, synaptogenesis, memory and learning, as well as …

Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications

Y Dwivedi - Dialogues in clinical neuroscience, 2014 - Taylor & Francis
Major depressive disorder (MDD) is a major public health concern. Despite tremendous
advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a …

The role of microRNAs in osteoclasts and osteoporosis

P Tang, Q Xiong, W Ge, L Zhang - RNA biology, 2014 - Taylor & Francis
Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can
lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone …

[HTML][HTML] MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns

M Abu-Halima, C Backes, P Leidinger, A Keller… - Fertility and sterility, 2014 - Elsevier
Objective To investigate the expression profiles of microRNA (miRNA) in human testes
showing different histopathological patterns. Design Microarray with quantitative real-time …