Cancer results from dysregulation of growth and survival pathways in normal stem cells and
progenitors. Identifying the cells from which a tumor arises can facilitate the development of …

Wilms tumor recapitulates the development of the kidney and represents a unique
opportunity to understand the relationship between normal and tumor development. This …

Improvements in childhood and adolescent cancer mortality and survival rates have
continued in recent years, but the rate of progress has been greater in hematologic …

DDX3X-MLLT10 fusion in adults with NOTCH1 positive T-cell acute lymphoblastic leukemia -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

In recent years, there has been a boom in the amount of genome-wide sequencing data that
has uncovered important and unappreciated links between certain genes, families of genes …

The recent deluge of cancer genomics data provides a tremendous opportunity for the
discovery of detailed mechanisms of tumorigenesis and the development of therapeutics …

The specific mechanisms how lung cancer cells harboring epidermal growth factor receptor
(EGFR) activating mutations can survive treatment with EGFR-tyrosine kinase inhibitors …

Mouse models have increased our understanding of the pathogenesis of medulloblastoma
(MB), the most common malignant pediatric brain tumor that often forms in the cerebellum. A …

Plate‐like osteoma cutis (PLOC) is a dermatological disorder characterized by superficial
ossification and rarely occurs without any underlying tissue abnormalities or pre‐existing …

Brain tumors have frequently been associated with a neural stem cell (NSC) origin and
contain stem-like tumor cells, so-called brain tumor stem cells (BTSCs) that share many …