Currently, the treatment of childhood medulloblastoma (MB) is tailored to risk groups defined
by clinical parameters. Growing evidence of tumoral heterogeneity is apparent as response …

The post‐ENCODE era shapes now a new biomedical research direction for understanding
transcriptional and signaling networks driving gene expression and core cellular processes …

As next-generation sequencing becomes a clinical tool, a full understanding of the variables
affecting sequencing analysis output is required. Through the International Cancer Genome …

Cigarette smoking is one of the most important risk factors for kidney cancer, but the
molecular mechanism is poorly understood. To examine the expression change of histone …

Recurrent chromosomal deletions in cancer are typically thought to harbor tumor
suppressors. In a recent publication in Nature, Northcott and colleagues identify a novel …

Cancer is by and large caused by a combination of genetic lesions and obstructed gene
expression patterns that put afflicted cells in a growth advantage. Recent research has …

Medulloblastoma is the most common paediatric malignant tumour. To identify altered
genetic events in a comprehensive manner, we recently performed exome sequencing of a …

The emergence of next generation DNA sequencing technology is enabling high-resolution
cancer genome analysis. Large-scale projects like the International Cancer Genome …

癌症的基因组测序对于癌症的预防, 诊断, 预后, 治疗以及基础生物学研究都有巨大的潜在的应用
价值, 正是由于其方向广泛, 所以基因组测序的方案制定对于实现特定的研究目标 …