Calorie restriction without malnutrition, commonly referred to as dietary restriction (DR),
results in a well-documented extension of life span. DR also produces significant, long …

Aims/hypothesis Obesity is associated with ageing and increased energy intake, while
restriction of energy intake improves health and longevity in multiple organisms; the NAD+ …

In a previous study, we have demonstrated that a supplementation of a high-fat diet with a
quinoa extract enriched in 20-hydroxyecdysone (QE) or pure 20-hydroxyecdysone (20E) …

Adipocyte differentiation and function have become areas of intense focus in the field of
energy metabolism; however, understanding the role of specific genes in the establishment …

We have previously reported that the expression of mitochondrial deacetylase SIRT3 is high
in the slow oxidative muscle and that the expression of muscle SIRT3 level is increased by …

The skeletal muscles in Duchenne muscular dystrophy and the mdx mouse model lack
functional dystrophin and undergo repeated bouts of necrosis, regeneration, and growth …

A high-calorie diet accompanied by low levels of physical activity (PA) accounts for the
widespread prevalence of obesity today, and yet some people remain lean even in this …

Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of
glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is …

The incidences of obesity and type 2 diabetes are rapidly increasing and have evolved into
a global epidemic. In this study, we analyzed the molecular effects of high-fat diet (HFD) …

Aims/hypothesis Increased extracellular matrix (ECM) collagen is a characteristic of muscle
insulin resistance. Matrix metalloproteinase (MMP) 9 is a primary enzyme that degrades …