Abstract Bscl2−/− mice recapitulate many of the major metabolic manifestations in
Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) individuals, including …

Despite the capacity of estrogens to favorably regulate body composition and glucose
homeostasis, their use to combat obesity and type 2 diabetes is not feasible, because they …

Phosphodiesterase 10A (PDE10A) is a novel therapeutic target for the treatment of
schizophrenia. Here we report a novel role of PDE10A in the regulation of caloric intake and …

Protein-tyrosine phosphatase 1B (PTP1B) regulates food intake (FI) and energy expenditure
(EE) by inhibiting leptin signaling in the hypothalamus. In peripheral tissues, PTP1B …

Type 2 diabetes is growing at epidemic proportions, and pharmacological interventions are
being actively sought. This study examined the effect of a novel neuroprotective …

Some second-generation antipsychotics (SGAs) increase insulin resistance and fat
oxidation, but counter intuitively they do not activate lipolysis. This seems unsustainable for …

Obesity is one of the largest health problems facing the world today. Although twin and
family studies suggest about two-thirds of obesity is caused by genetic factors, only a small …

Three types of beta adrenergic receptors (ARβ1–3) mediate the sympathetic activation of
brown adipose tissue (BAT), the key thermogenic site for mice which is also present in adult …

The initial cause of post-neutering weight gain in male cats is not entirely known. There is
evidence that energy intake (EI) increases rapidly post-neutering, but it is not clear if …

Obesity resistance due to elevated orexin signaling is accompanied by high levels of
spontaneous physical activity (SPA). The behavioral and neural mechanisms underlying this …