[HTML][HTML] Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms
SP Haugvik, L Gorunova, L Haugom… - Oncology …, 2014 - spandidos-publications.com
The pathogenesis of sporadic pancreatic neuroendocrine neoplasms (PNENs) is poorly
understood. To gain insight into the genetic mechanisms underlying this tumor entity, we …
understood. To gain insight into the genetic mechanisms underlying this tumor entity, we …
[HTML][HTML] Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer
B Lawrence, C Blenkiron, K Parker, P Tsai… - NPJ genomic …, 2018 - nature.com
Pancreatic neuroendocrine tumors (pNETs) are uncommon cancers arising from pancreatic
islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression …
islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression …
Genomic characterization of a well-differentiated grade 3 pancreatic neuroendocrine tumor
LM Williamson, M Steel… - Molecular …, 2019 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine neoplasms (PanNENs) represent a minority of pancreatic
neoplasms that exhibit variability in prognosis. Ongoing mutational analyses of PanNENs …
neoplasms that exhibit variability in prognosis. Ongoing mutational analyses of PanNENs …
[HTML][HTML] Integrated genomic and clinicopathologic approach distinguishes pancreatic grade 3 neuroendocrine tumor from neuroendocrine carcinoma and identifies a …
SE Umetsu, S Kakar, O Basturk, GE Kim, D Chatterjee… - Modern Pathology, 2023 - Elsevier
Distinguishing grade 3 pancreatic neuroendocrine tumor (G3 PanNET) from neuroendocrine
carcinoma (PanNEC) is a known diagnostic challenge, and accurate classification is critical …
carcinoma (PanNEC) is a known diagnostic challenge, and accurate classification is critical …
Multifocality is not associated with worse survival in sporadic pancreatic neuroendocrine tumors
H Gudmundsdottir, RP Graham… - Journal of Surgical …, 2021 - Wiley Online Library
Abstract Background and Objectives Pancreatic neuroendocrine tumors (pNETs) in patients
with hereditary cancer syndromes are typically multifocal. In contrast, sporadic pNETs are …
with hereditary cancer syndromes are typically multifocal. In contrast, sporadic pNETs are …
Convergence between germline and somatic mutations in pancreatic neuroendocrine tumors
C Ling, X Hong, M Xu, Y Wang, X Ma… - European Journal of …, 2022 - academic.oup.com
Objectives The pancreatic neuroendocrine tumors (PanNETs) are a group of clinically
heterogeneous neoplasms. Although previous studies illustrated the somatic mutation …
heterogeneous neoplasms. Although previous studies illustrated the somatic mutation …
[HTML][HTML] Genomic landscape of pancreatic neuroendocrine tumors
N Gebauer, C Schmidt-Werthern… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To investigate the prognostic role of genomic stability and copy number alterations
(CNAs) pancreatic neuroendocrine tumors (PanNETs). METHODS: A high-resolution array …
(CNAs) pancreatic neuroendocrine tumors (PanNETs). METHODS: A high-resolution array …
Recurrent loss of heterozygosity in pancreatic neuroendocrine tumors
M Parilla, D Chapel, JF Hechtman… - The American journal …, 2022 - journals.lww.com
Chromosomal aneuploidies are prognostic markers across a wide variety of tumor types,
and recent literature suggests that pancreatic neuroendocrine tumors are no different. In this …
and recent literature suggests that pancreatic neuroendocrine tumors are no different. In this …
Pancreatic neuroendocrine neoplasms: updates on genomic changes in inherited tumour syndromes and sporadic tumours based on WHO classification
H Ishida, AK Lam - Critical Reviews in Oncology/Hematology, 2022 - Elsevier
Pancreatic neuroendocrine neoplasms (PanNENs) are the neuroendocrine neoplasms with
greatest rate of increase in incidence. Approximately 10% of PanNENs arise as inherited …
greatest rate of increase in incidence. Approximately 10% of PanNENs arise as inherited …
Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype
BACKGROUND Nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) may be
sporadic or inherited because of germline mutations associated with von Hippel‐Lindau …
sporadic or inherited because of germline mutations associated with von Hippel‐Lindau …