The pathogenesis of sporadic pancreatic neuroendocrine neoplasms (PNENs) is poorly
understood. To gain insight into the genetic mechanisms underlying this tumor entity, we …

Pancreatic neuroendocrine tumors (pNETs) are uncommon cancers arising from pancreatic
islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression …

Pancreatic neuroendocrine neoplasms (PanNENs) represent a minority of pancreatic
neoplasms that exhibit variability in prognosis. Ongoing mutational analyses of PanNENs …

Distinguishing grade 3 pancreatic neuroendocrine tumor (G3 PanNET) from neuroendocrine
carcinoma (PanNEC) is a known diagnostic challenge, and accurate classification is critical …

Abstract Background and Objectives Pancreatic neuroendocrine tumors (pNETs) in patients
with hereditary cancer syndromes are typically multifocal. In contrast, sporadic pNETs are …

Objectives The pancreatic neuroendocrine tumors (PanNETs) are a group of clinically
heterogeneous neoplasms. Although previous studies illustrated the somatic mutation …

AIM: To investigate the prognostic role of genomic stability and copy number alterations
(CNAs) pancreatic neuroendocrine tumors (PanNETs). METHODS: A high-resolution array …

Chromosomal aneuploidies are prognostic markers across a wide variety of tumor types,
and recent literature suggests that pancreatic neuroendocrine tumors are no different. In this …

Pancreatic neuroendocrine neoplasms (PanNENs) are the neuroendocrine neoplasms with
greatest rate of increase in incidence. Approximately 10% of PanNENs arise as inherited …

BACKGROUND Nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) may be
sporadic or inherited because of germline mutations associated with von Hippel‐Lindau …