Genome-wide association studies have identified common variants in transcription factor 4
(TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and …

Haploinsufficiency of TCF4 causes Pitt-Hopkins syndrome (PTHS): a severe form of mental
retardation with phenotypic similarities to Angelman, Mowat-Wilson and Rett syndromes …

The human transcription factor 4 gene (TCF4) encodes a helix–loop–helix transcription
factor widely expressed throughout the body and during neural development. Mutations in …

Transcription factor 4 is a class I basic helix-loop-helix transcription factor regulating gene
expression. Altered TCF4 gene expression has been linked to non-syndromic intellectual …

Common SNPs in the transcription factor 4 (TCF4; ITF2, E2‐2, SEF‐2) gene, which encodes
a basic Helix‐Loop‐Helix (bHLH) transcription factor, are associated with schizophrenia …

Tcf4 has been linked to autism, schizophrenia, and Pitt-Hopkins Syndrome (PTHS) in
humans, suggesting a role for Tcf4 in brain development and importantly cortical …

The TCF4 gene is the subject of numerous and varied investigations of it's role in the
genesis of neuropsychiatric disease. The gene has been identified as the cause of Pitt …

Background Common genetic variants in and around the gene encoding transcription factor
4 (TCF4) are associated with an increased risk of schizophrenia. Conversely, rare damaging …

Background Haploinsufficiency of the class I bHLH transcription factor TCF4 causes Pitt-
Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants …

Abstract Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and
other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the …