The development of an effective vaccine against tuberculosis (Tb) represents one of the
major medical challenges of this century. Mycobacterium bovis Bacille Calmette-Guerin …

Background The functional equilibrium between natural regulatory T cells (Treg) and effector
T cells can affect the issue of numerous infections. In unvaccinated mice, the influence of …

Tuberculosis (TB) is one of the top 10 causes of mortality worldwide from a single infectious
agent and has significant implications for global health. A major hurdle in the development …

Mycobacterium tuberculosis uses numerous mechanisms to avoid elimination by the
infected host. In this study, we investigated the possibility whether, similar to other …

Regulatory T cells (Tregs) play a critical role in maintaining tissue homeostasis and
preventing the development of immunopathology. Depletion of REGulatory T cell (DEREG) …

Using two mouse strains with different abilities to generate interferon (IFN)‐γ production after
Mycobacterium tuberculosis infection, we tested the hypothesis that the frequency and …

T regulatory cells (Treg) constitute a specialized subset of T cells that play a pivotal role in
preventing the occurrence of autoimmune diseases by suppressing deleterious activities of …

The development of effective vaccines against life‐threatening pathogens in human
diseases represents one of the biggest challenges in biomedical science. Vaccines …

Immunity against different Mycobacteria species targeting the lung requires distinctly
different pulmonary immune responses for bacterial clearance. Many parameters of …

Mycobacterium bovis bacillus Calmette-Guérin (M. bovis BCG), the only currently available
vaccine against tuberculosis, has been reported to induce regulatory T cells in humans. The …