Chronic inflammation is known to be associated with prostate cancer development, but how
epithelium-associated cancer-initiating events cross talk to inflammatory cells during …

Genetic inactivation of PTEN is common in prostate cancer and correlates with poorer
prognosis. We previously identified CHD1 as an essential gene in PTEN-deficient cancer …

Background Inflammation and genetic instability are enabling characteristics of prostate
carcinoma (PCa). Inactivation of the tumour suppressor gene phosphatase and tensin …

Prostate-specific deletion of Pten in mice has been reported to recapitulate histological
progression of human prostate cancer. To improve on this model, we introduced the …

PTEN loss is prognostic for patient relapse post-radiotherapy in prostate cancer (CaP).
Infiltration of tumor-associated macrophages (TAMs) is associated with reduced disease …

Background Accumulating evidence shows that tumor cell–specific genomic changes can
influence the cross talk between cancer cells and the surrounding tumor microenvironment …

Chronic inflammation has been shown to promote the initiation and progression of diverse
malignancies by inducing genetic and epigenetic alterations. In this study, we investigate an …

Prostate cancer is the second most common cause of cancer mortality in men in the United
States. As is the case for other tumor types, accumulating evidence suggests an important …

Infiltrating macrophages are a key component of inflammation during tumorigenesis, but the
direct evidence of such linkage remains unclear. We report here that persistent coculturing …

Abstract PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …