Radiation therapy (RT) continues to be one of the most popular treatment options for
localized prostate cancer (CaP). Local CaP recurrence after RT is a pattern of treatment …

Radioresistance is a major challenge in prostate cancer (CaP) radiotherapy (RT). In this
study, we investigated the role and association of epithelial–mesenchymal transition (EMT) …

Abstract The PI3K/Akt/mTOR pathway has a central role in cancer metastasis and
radiotherapy. To develop effective therapeutics to improve radiosensitivity, understanding …

Abstract The phosphatidylinositol-3-kinase/Akt and the mammalian target of rapamycin
(PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in …

Prostate cancer (PCa) is the second most commonly diagnosed cancer worldwide.
Radiotherapy remains one of the first-line treatments in localised disease and may be used …

Radiation therapy (RT) is commonly used for the treatment of localized prostate cancer
(PCa). However, cancer cells often develop resistance to radiation through unknown …

METHODS: An up-dated review of several thorough studies on such matter. RESULTS: The
plenty of intriguing knowledge acquisitions about the prostate cancer radioresistance …

Radiotherapy and surgery are curative treatment options for localized prostate cancer (PCa)
with a 5-year survival rate of nearly 100%. Once PCa cells spread into distant organs, such …

Tissue markers may be helpful in enhancing prediction of radiation therapy (RT) failure of
prostate cancer (PCa). Among the various biomarkers tested in Phase III randomized trials …

Cancer stem cells (CSCs) in prostate cancer (CaP) are regarded as major contributors to
radioresistance due to complex mechanisms including enhanced DNA repair, increased …